_tcm18-11403.gif )
The home of cutting-edge research on the development of alternative sustainable technologies.
Subscribers
Non-subscribers
- Purchase article PDF [£27 + taxes]
- Purchase article PDF member offer [£5 + taxes]
Free access
Paper
Green Chem., 2009, 11, 1881 - 1888, DOI: 10.1039/b916124b
Microwave-assisted synthesis of quinazolinone derivatives by efficient and rapid iron-catalyzed cyclization in water
Xiaodong Zhang, Deju Ye, Haifeng Sun, Diliang Guo, Jiang Wang, He Huang, Xu Zhang, Hualiang Jiang and Hong Liu
A green, rapid, and efficient method was developed for synthesizing quinazolinone derivatives from substituted 2-halobenzoic acids and amidines via microwave-assisted iron-catalyzed cyclization with or without ligand in water (methods A and B) or DMF (methods C and D). With these methods, moderate to high yields of the desired products can be obtained from even inactive substrates, such as guanidines. To the best of our knowledge, this is the first report on the synthesis of N-heterocyclic compounds by iron-catalyzed C–N coupling in aqueous media.
RSS feed