Issue 2, 2003
From the journal:

Journal of Materials Chemistry

A novel route to highly porous bioactive silica gels

Simon R. Hall,a   Dominic Walsh,a   David Green,b   Richard Oreffob  and  Stephen Mann*a  

* Corresponding authors

a School of Chemistry, University of Bristol, Bristol, UK
E-mail: S.Mann@bristol.ac.uk

b Bone Tissue Engineering Group, University Orthopaedics, MP817, Southampton General Hospital, Tremona Road, Southampton, UK
E-mail: R.Oreffo@soton.ac.uk

Abstract

Silica gels with a distribution of pore sizes from the sub-micrometre to hundreds of micrometers were produced by a novel method in which precursor solutions, such as a colloidal silica sol or pre-hydrolyzed tetraethoxysilane (TEOS), were solidified in the presence of a space-filling agent (CaCO3) and CO2 generator (sodium bicarbonate–hydrogen pyrophosphate). A range of macroporous organically modified silica gels with covalently linked phenyl, amino or thiol moieties were also prepared by a similar method using mixtures of TEOS and organotrialkoxysilanes. The highly porous monoliths were characterized by SEM, FTIR and solid state 29Si and 13C MAS NMR spectroscopies. In vitro bioactivity of the gels was demonstrated by their ability to nucleate calcium phosphate from simulated body fluid, bind and slowly release the drug ibuprofen, and support in vitro adhesion and proliferation of human osteoprogenitor cells and C2C12 pro-myoblast cells.

Graphical abstract: A novel route to highly porous bioactive silica gels

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Article information

DOI
https://doi.org/10.1039/B209300F
Article type
Paper
Submitted
24 Sep 2002
Accepted
18 Dec 2002
First published
13 Jan 2003

J. Mater. Chem., 2003,13, 186-190

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A novel route to highly porous bioactive silica gels

S. R. Hall, D. Walsh, D. Green, R. Oreffo and S. Mann, J. Mater. Chem., 2003, 13, 186 DOI: 10.1039/B209300F

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