Issue 26, 2007

Antibody conjugated magnetic PLGA nanoparticles for diagnosis and treatment of breast cancer

Abstract

DOX–magnetic PLGA nanoparticles conjugated with well-tailored antibodies were synthesized for the detection and therapy of breast cancer. Magnetic nanocrystals embedded in polymeric nanoparticles did not inhibit the nanoparticle formulation or drug release kinetics. The multimodal nanoparticles demonstrated remarkable cancer cell affinity and ultrasensitivity via magnetic resonance imaging. Furthermore, the loaded anticancer drugs were released and sustained for three weeks.

Graphical abstract: Antibody conjugated magnetic PLGA nanoparticles for diagnosis and treatment of breast cancer

Article information

Article type
Paper
Submitted
28 Feb 2007
Accepted
17 Apr 2007
First published
27 Apr 2007

J. Mater. Chem., 2007,17, 2695-2699

Antibody conjugated magnetic PLGA nanoparticles for diagnosis and treatment of breast cancer

J. Yang, C. Lee, J. Park, S. Seo, E. Lim, Y. J. Song, J. Suh, H. Yoon, Y. Huh and S. Haam, J. Mater. Chem., 2007, 17, 2695 DOI: 10.1039/B702538F

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