Protein-passivated Fe3O4nanoparticles: low toxicity and rapid heating for thermal therapy

Bappaditya Samanta; Haoheng Yan; Nicholas O. Fischer; Jing Shi; D. Joseph Jerry; Vincent M. Rotello

doi:10.1039/B718745A

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Protein-passivated Fe₃O₄nanoparticles: low toxicity and rapid heating for thermal therapy†

Bappaditya Samanta,‡^a Haoheng Yan,‡^b Nicholas O. Fischer,^b Jing Shi,^a D. Joseph Jerry^c and Vincent M. Rotello*^a

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* Corresponding authors

^a Department of Chemistry, University of Massachusetts, USA
E-mail: rotello@chem.umass.edu
Fax: +413-545-4490
Tel: +413-545-2058

^b Molecular and Cellular Biology Program, University of Massachusetts, USA

^c Department of Veterinary and Animal Science, University of Massachusetts, USA

Abstract

Thermotherapy is a promising technique for the minimally invasive elimination of solid tumors. Here we report the fabrication of protein-coated iron oxide NPs (12 nm core) for use as thermal therapeutic agents. These albumin-passivated NPs are stable under physiological conditions, with rapid heating and cell killing capacity upon alternating magnetic field (AMF) exposure. The mode of action is specific: no measurable cytotoxicity was observed for the particle without AMF or for AMF exposure without the particle.

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Supplementary files

Histogram, TGA and stability assay data of nanoparticles PDF (3127K)

Article information

DOI: https://doi.org/10.1039/B718745A
Article type: Paper
Submitted: 04 Dec 2007
Accepted: 23 Jan 2008
First published: 19 Feb 2008

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J. Mater. Chem., 2008,18, 1204-1208

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Protein-passivated Fe₃O₄nanoparticles: low toxicity and rapid heating for thermal therapy

B. Samanta, H. Yan, N. O. Fischer, J. Shi, D. J. Jerry and V. M. Rotello, J. Mater. Chem., 2008, 18, 1204 DOI: 10.1039/B718745A

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Journal of Materials Chemistry