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First Lab on a Chip Video Abstract: Nanofluidic technology for biomolecule applications - a critical review
09 February 2010
In this first Lab on a Chip video abstract Jan Eijkel describes nanofluidic phenomena particularly as they relate to biomolecule analysis within nanofluidic devices
Male fertility exam at home
04 February 2010
First step towards microfluidic system for complete quality analysis of semen
Emerging Investigators Call for Papers
14 December 2009
A call for papers for the special issue has been announced, and the journal's editors will begin accepting submissions on February 1, 2010.
Lab on a Chip video channel
Find out more about Lab on a Chip videos
Contents list for Lab on a Chip, issue 4, 2010
Front cover
Lab Chip, 2010, 10, 397
DOI: 10.1039/c001268h
Inside front cover
Lab Chip, 2010, 10, 398
DOI: 10.1039/c001269f
Contents
Lab Chip, 2010, 10, 399
DOI: 10.1039/c001270j
Highlight
Research Highlights
Petra S. Dittrich,
Lab Chip, 2010, 10, 409
DOI: 10.1039/b927233j
Petra Dittrich reviews the current literature in miniaturisation and related technologies.
Communications
Implementation of a color-capable optofluidic microscope on a RGB CMOS color sensor chip substrate
Shuo Pang, Xiquan Cui, John DeModena, Ying Min Wang, Paul Sternberg and Changhuei Yang,
Lab Chip, 2010, 10, 411
DOI: 10.1039/b919004j
This communication reports the implementation of a color-capable on-chip lensless microscope system, color optofluidic microscope (color OFM). The imaging of double stained C. elegans with lacZ expression by the color OFM demonstrates its potential in on-chip phenotype analysis applications.
Morphology-based assessment of Cd2+ cytotoxicity using microfluidic image cytometry (
FIC)
Min Jung Kim, Kook Hee Lim, Hyun Ju Yoo, Seog Woo Rhee and Tae Hyun Yoon,
Lab Chip, 2010, 10, 415
DOI: 10.1039/b920890a
Morphology-based microfluidic image cytometry (FIC) was developed and presented here as a simple, efficient, and label-free in situ method for quantifying the progress of a cell death event, which can be adapted to HTS platforms for various in vitro cell-based assays.
Critical Review
Integration and detection of biochemical assays in digital microfluidic LOC devices
Lidija Malic, Daniel Brassard, Teodor Veres and Maryam Tabrizian,
Lab Chip, 2010, 10, 418
DOI: 10.1039/b917668c
This paper reviews the state of the art of the EWOD LOC device coupling and integration with analytical detection technologies for biomedical applications. Miniaturized and integrated systems are highlighted to describe current trends and future outlook into the direction of research in this exciting field.
Frontier
Worm chips: Microtools for C. elegans biology
Nikos Chronis,
Lab Chip, 2010, 10, 432
DOI: 10.1039/b919983g
Here, we discuss the applications, capabilities and future directions of a new family of worm manipulation tools: the worm chips.
Papers
Selective isolation of live/dead cells using contactless dielectrophoresis (cDEP)
Hadi Shafiee, Michael B. Sano, Erin A. Henslee, John L. Caldwell and Rafael V. Davalos,
Lab Chip, 2010, 10, 438
DOI: 10.1039/b920590j
Contactless dielectrophoresis (cDEP) is a recently developed method of cell manipulation in which the electrodes are physically isolated from the sample. Here we present two microfluidic devices capable of selectively isolating live human leukemia cells from dead cells utilizing their electrical signatures.
A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip
Jong Hwan Sung, Carrie Kam and Michael L. Shuler,
Lab Chip, 2010, 10, 446
DOI: 10.1039/b917763a
This article demonstrates for the first time the combination of a microfluidic system (in vitro) with a mathematical PK–PD (in silico) model to quantitatively analyze the drug's effect.
Designed pneumatic valve actuators for controlled droplet breakup and generation
Jae-Hoon Choi, Seung-Kon Lee, Jong-Min Lim, Seung-Man Yang and Gi-Ra Yi,
Lab Chip, 2010, 10, 456
DOI: 10.1039/b915596a
The dynamic breakup of emulsion droplets was induced in double-layered microfluidic devices equipped with designed pneumatic actuators, in which the droplet breakup mode was significantly affected by the shape and layout of the control valves.
Smart
polymeric microfluidics fabricated by plasma processing: controlled wetting, capillary filling and hydrophobic valving
Katerina Tsougeni, Dimitris Papageorgiou, Angeliki Tserepi and Evangelos Gogolides,
Lab Chip, 2010, 10, 462
DOI: 10.1039/b916566e
A planar technology using direct lithography on the polymer surface, followed by deep oxygen plasma etching and selective deposition, is proposed as an alternative method for smart polymeric microfluidic fabrication.
The extraction of liquid, protein molecules and yeast cells from paper through surface acoustic wave atomization
Aisha Qi, Leslie Yeo, James Friend and Jenny Ho,
Lab Chip, 2010, 10, 470
DOI: 10.1039/b915833b
Paper-based microfluidics are enhanced by extraction and atomization of fluids from paper at will using surface acoustic wave irradiation. Large, biologically significant proteins like BSA and ovalbumin and yeast cells tolerate the process with insignificant damage.
Electrochemical sensing in paper-based microfluidic devices
Zhihong Nie, Christian A. Nijhuis, Jinlong Gong, Xin Chen, Alexander Kumachev, Andres W. Martinez, Max Narovlyansky and George M. Whitesides,
Lab Chip, 2010, 10, 477
DOI: 10.1039/b917150a
This paper describes the fabrication and the performance of microfluidic paper-based electrochemical sensing devices that are capable of quantifying the concentrations of various analytes (e.g., heavy-metal ions and glucose) in aqueous solutions.
Dynamic memory in a microfluidic system of droplets traveling through a simple network of microchannels
Olgierd Cybulski and Piotr Garstecki,
Lab Chip, 2010, 10, 484
DOI: 10.1039/b912988j
The flow of droplets through a simple microfluidic network of channels exhibits stable temporal sequences of trajectories of droplets that can be switched between each other with a transient stimulus.
Wet-etching of structures with straight facets and adjustable taper into glass substrates
Nikola Pekas, Qing Zhang, Matthieu Nannini and David Juncker,
Lab Chip, 2010, 10, 494
DOI: 10.1039/b912770d
We present a simple wet-etch process based on a single masking step for the fabrication of microchannels in glass with straight, tapered sidewalls with a defined angle by controlling the lateral etch rate of a sacrificial mask. Multi-faceted sidewalls can also be made by varying the lateral etch rate during the process.
A microchip fabricated with a vapor-diffusion self-assembled-monolayer method to transport droplets across superhydrophobic to hydrophilic surfaces
Yu-Hsuan Lai, Jing-Tang Yang and Dar-Bin Shieh,
Lab Chip, 2010, 10, 499
DOI: 10.1039/b917624a
We propose an approach that combines a structure gradient and a self-assembled-monolayer (SAM) gradient to fabricate a microchip to transport a biochemical droplet across superhydrophobic to hydrophilic surfaces.
Microfluidic isolation and transcriptome analysis of serum microvesicles
Chihchen Chen, Johan Skog, Chia-Hsien Hsu, Ryan T. Lessard, Leonora Balaj, Thomas Wurdinger, Bob S. Carter, Xandra O. Breakefield, Mehmet Toner and Daniel Irimia,
Lab Chip, 2010, 10, 505
DOI: 10.1039/b916199f
This article describes a rapid microfluidic immunoaffinity method to isolate microvesicles (exosomes) that carry proteins, lipids and nucleic acids derived from the host cell. RNA of high quality can be extracted from these microvesicles providing a source of information about the genetic status of tumors to serve as biomarkers for diagnosis and prognosis of cancer.
Droplet on demand system utilizing a computer controlled microvalve integrated into a stiff polymeric microfluidic device
Krzysztof Churski, Jacek Michalski and Piotr Garstecki,
Lab Chip, 2010, 10, 512
DOI: 10.1039/b915155a
An integrated microvalve compatible with polymeric and glass microfluidic devices allows for formation of droplets and bubbles on demand.
Technical Notes
Modular integration of electronics and microfluidic systems using flexible printed circuit boards
Amy Wu, Lisen Wang, Erik Jensen, Richard Mathies and Bernhard Boser,
Lab Chip, 2010, 10, 519
DOI: 10.1039/b922830f
A modular approach for embedding integrated electronic circuits with microfluidic systems is presented. The subsystems are developed and optimized independently using standard fabrication techniques and bonded with a PDMS adhesion layer.
Rapid, cost-efficient fabrication of microfluidic reactors in thermoplastic polymers by combining photolithography and hot embossing
Jesse Greener, Wei Li, Judy Ren, Dan Voicu, Viktoriya Pakharenko, Tian Tang and Eugenia Kumacheva,
Lab Chip, 2010, 10, 522
DOI: 10.1039/b918834g
We report a cost-efficient process for producing microfluidic reactors in thermoplastic materials by (i) fabricating an imprint template which consist of a patterned photoresist deposited on a metal plate; (ii) thermoembossing of the template features into a polymer sheet; and (iii) low-temperature sealing of the embossed sheet and a planar thermoplastic sheet.
Back matter
Lab Chip, 2010, 10, 525
DOI: 10.1039/c001271h
Back cover
Lab Chip, 2010, 10, 527
DOI: 10.1039/c001272f
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