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Chips & Tips: A simple and economical holder for casting PDMS chips
20 November 2009
Gang Li and co-workers demonstrate a simple and economical holder for casting PDMS chips
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20 November 2009
Claudio Nastruzzi and colleagues demonstrate "custom made" production of cheap Luer lock adapters
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Contents list for Lab on a Chip, issue 23, 2009
Front cover
Lab Chip, 2009, 9, 3313
DOI: 10.1039/B922066F
Inside front cover
Lab Chip, 2009, 9, 3314
DOI: 10.1039/B922067B
Contents and Highlights in Chemical Biology
Lab Chip, 2009, 9, 3315
DOI: 10.1039/B922068M
Highlight
Research Highlights
Lab Chip, 2009, 9, 3325
DOI: 10.1039/b921117a
Petra Dittrich reviews the current literature in miniaturisation and related technologies.
Focus
IP or no IP: that is the question
Holger Becker,
Lab Chip, 2009, 9, 3327
DOI: 10.1039/b920548a
Holger Becker discusses IP and patent strategies—part of a series of Focus articles on the commercialization of microfluidics.
Papers
Toward one-step point-of-care immunodiagnostics using capillary-driven microfluidics and PDMS substrates
Luc Gervais and Emmanuel Delamarche,
Lab Chip, 2009, 9, 3330
DOI: 10.1039/b906523g
The one-step chip only requires the addition of sample to detect C-reactive protein at concentrations of 10 ng mL-1 in 3 minutes and below 1 ng mL-1 within 14 minutes.
Tunable shrink-induced honeycomb microwell arrays for uniform embryoid bodies
Diep Nguyen, Silin Sa, Jonathan D. Pegan, Brent Rich, Guangxin Xiang, Kara E. McCloskey, Jennifer O. Manilay and Michelle Khine,
Lab Chip, 2009, 9, 3338
DOI: 10.1039/b914091c
We report an ultra-rapid fabrication and culture method utilizing a laser-jet printer to generate closely arrayed honeycomb microwells of tunable sizes for the induction of uniform EBs from single cell suspension.
Multiplex pressure measurement in microsystems using volume displacement of particle suspensions
Kwanghun Chung, Hyewon Lee and Hang Lu,
Lab Chip, 2009, 9, 3345
DOI: 10.1039/b911480g
This paper presents a simple, inexpensive, fast and accurate pressure measurement method that can be integrated with many microfluidic applications.
Continuous particle separation in a microfluidic channel via standing surface acoustic waves (SSAW)
Jinjie Shi, Hua Huang, Zak Stratton, Yiping Huang and Tony Jun Huang,
Lab Chip, 2009, 9, 3354
DOI: 10.1039/b915113c
On-chip continuous particle separation is realized through standing surface acoustic wave (SSAW)-induced acoustophoresis in a microfluidic channel.
Label-free and highly sensitive biomolecular detection using SERS and electrokinetic preconcentration
Hansang Cho, Brian Lee, Gang L. Liu, Ajay Agarwal and Luke P. Lee,
Lab Chip, 2009, 9, 3360
DOI: 10.1039/b912076a
We present a label-free and highly sensitive biomolecular detection method that combines surface-enhanced Raman scattering (SERS) spectroscopy and an electrokinetic preconcentration technique.
Rapid automated cell quantification on HIV microfluidic devices
Mohamad A. Alyassin, SangJun Moon, Hasan O. Keles, Fahim Manzur, Richard L. Lin, Edward Hæggstrom, Daniel R. Kuritzkes and Utkan Demirci,
Lab Chip, 2009, 9, 3364
DOI: 10.1039/b911882a
We use image analysis to segment and count CD4 T lymphocytes captured on lab-chip and labeled with multi-fluorescent colors. This method is validated by automated and manual results using HIV-infected patient samples.
Single cell electric impedance topography: Mapping membrane capacitance
Sameera Dharia, Harold E. Ayliffe and Richard D. Rabbitt,
Lab Chip, 2009, 9, 3370
DOI: 10.1039/b912881f
A platform has been designed to monitor local changes in the capacitive properties of isolated cell membranes during pharmacological or pipette-based excitation.
Three-dimensional cell culture array using magnetic force-based cell patterning for analysis of invasive capacity of BALB/3T3/v-src
Mina Okochi, Sho Takano, Yayoi Isaji, Takeshi Senga, Michinari Hamaguchi and Hiroyuki Honda,
Lab Chip, 2009, 9, 3378
DOI: 10.1039/b909304d
A three-dimensional cell culture system has been fabricated using a magnetic force based cell patterning method, demonstrating a facile approach for the analysis of invasive capacity of BALB/3T3/v-src cells arranged in array-like patterns.
Lipase-catalyzed synthesis of isoamyl acetate in an ionic liquid/n–heptane two-phase system at the microreactor scale
Andrej Pohar, Igor Plazl and Polona 
nidar
i
–Plazl,
Lab Chip, 2009, 9, 3385
DOI: 10.1039/b915151f
Highly efficient lipase-catalyzed isoamyl acetate synthesis was achieved in a continuously operated 
-shaped microreactor with the [bmpyr][dca]/n-heptane biphasic system. This was a consequence of efficient reaction–diffusion dynamics in the microchannel system, where the developed flow pattern resulting from very high relative viscosity of both phases and amphiphilic properties of the enzyme provided a large interfacial area for the reaction and simultaneous product extraction.
A PMMA microfluidic droplet platform for in vitro protein expression using crude E. coli S30 extract
N. Wu, Y. Zhu, S. Brown, J. Oakeshott, T. S. Peat, R. Surjadi, C. Easton, P. W. Leech and B. A. Sexton,
Lab Chip, 2009, 9, 3391
DOI: 10.1039/b911581a
This paper reports the development of a robust microchip system, which, for the first time, demonstrated the capability of synthesizing protein using crude cell extract.
Hands-free sample preparation platform for nucleic acid analysis
T. Baier, T. E. Hansen-Hagge, R. Gransee, A. Crombé, S. Schmahl, C. Paulus, K. S. Drese, H. Keegan, C. Martin, J. J. O'Leary, L. Furuberg, L. Solli, P. Grønn, I. M. Falang, A. Karlgård, A. Gulliksen and F. Karlsen,
Lab Chip, 2009, 9, 3399
DOI: 10.1039/b910421f
A Lab-On-Chip system with an instrument is presented which is capable of performing total sample preparation and automated extraction of nucleic acid from human cell samples.
A microwave interferometric system for simultaneous actuation and detection of single biological cells
Graham A. Ferrier, Sean F. Romanuik, Douglas J. Thomson, Greg E. Bridges and Mark R. Freeman,
Lab Chip, 2009, 9, 3406
DOI: 10.1039/b908974h
An electrical approach for single-cell analysis wherein a 1.6 GHz microwave interferometer detects the capacitance changes (
C) produced by dielectrophoretically actuated single cells flowing past a coplanar interdigitated electrode pair.
Micro-fluidic actuation using magnetic artificial cilia
Francis Fahrni, Menno W. J. Prins and Leo J. van IJzendoorn,
Lab Chip, 2009, 9, 3413
DOI: 10.1039/b908578e
We demonstrate advanced fluid manipulations at the micro-scale using magnetic polymeric artificial cilia. The artificial cilia move in fluid up to frequencies of 50 Hz in the rotating magnetic field of a compact external electromagnet.
Passive microfluidic pumping using coupled capillary/evaporation effects
N. Scott Lynn and David S. Dandy,
Lab Chip, 2009, 9, 3422
DOI: 10.1039/b912213c
A small meniscus situated within a microreservoir will pump fluid through a microchannel at a steady-state with a flow rate dependent on the geometries of the microchannel and reservoir.
Technical Notes
Simple practical approach for sample loading prior to DNA extraction using a silica monolith in a microfluidic device
Kirsty J. Shaw, Domino A. Joyce, Peter T. Docker, Charlotte E. Dyer, John Greenman, Gillian M. Greenway and Stephen J. Haswell,
Lab Chip, 2009, 9, 3430
DOI: 10.1039/b913309g
A simple microfluidic device for on-chip DNA extraction is described whereby all reagents are stored on the device and movement is achieved using electro-osmotic pumping.
Towards an electrowetting-based digital microfluidic platform for magnetic immunoassays
Vincent Schaller, Anke Sanz-Velasco, Alexey Kalabukhov, Justin F. Schneiderman, Fredrik Öisjöen, Aldo Jesorka, Andrea Prieto Astalan, Anatol Krozer, Cristina Rusu, Peter Enoksson and Dag Winkler,
Lab Chip, 2009, 9, 3433
DOI: 10.1039/b912646e
We demonstrate ElectroWetting-On-Dielectric (EWOD) transport and SQUID gradiometer detection of magnetic nanoparticles (MNPs) suspended in a 2 µl de-ionized water droplet.
Removal of background signals from fluorescence thermometry measurements in PDMS microchannels using fluorescence lifetime imaging
Tom Robinson, Yolanda Schaerli, Robert Wootton, Florian Hollfelder, Christopher Dunsby, Geoff Baldwin, Mark Neil, Paul French and Andrew deMello,
Lab Chip, 2009, 9, 3437
DOI: 10.1039/b913293g
A method for removing unwanted fluorescence signals when measuring temperatures in microfluidic channels using optical thermometry is presented. Fluorescence lifetime images are constructed using a double exponential fit and fluid temperatures extracted from just a single component.
A microfluidic cell trap device for automated measurement of quantal catecholamine release from cells
Yuanfang Gao, Shantanu Bhattacharya, Xiaohui Chen, Syed Barizuddin, Shubhra Gangopadhyay and Kevin D. Gillis,
Lab Chip, 2009, 9, 3442
DOI: 10.1039/b913216c
An automated method is presented which uses microfluidic channels to trap cells over electrochemical electrodes (left) in order to amperometrically record release of transmitter from individual vesicles (right).
Back matter
Lab Chip, 2009, 9, 3447
DOI: 10.1039/B922069K
Back cover
Lab Chip, 2009, 9, 3451
DOI: 10.1039/B922070B
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