Contents list for Lab on a Chip, issue 13, 2010
Petra Dittrich reviews the current literature in miniaturisation and related technologies.
Microfabricated thermal modulator for comprehensive two-dimensional micro gas chromatography: design, thermal modeling, and preliminary testing
Sung-Jin Kim, Shaelah M. Reidy, Bruce P. Block, Kensall D. Wise, Edward T. Zellers and Katsuo Kurabayashi, Lab Chip, 2010, 10, 1647
We show the development of a microfabricated thermal modulator (TM), which plays a critical role in a comprehensive two-dimensional gas chromatography system.
Single-sided continuous optoelectrowetting (SCOEW) for droplet manipulation with light patterns
Sung-Yong Park, Michael A. Teitell and Eric P. Y. Chiou, Lab Chip, 2010, 10, 1655
We report on a single-sided continuous optoelectrowetting (SCOEW) mechanism that enables light-patterned electrowetting modulation for continuous droplet manipulation on an open, featureless, and photoconductive surface.
Introducing dip pen nanolithography as a tool for controlling stem cell behaviour: unlocking the potential of the next generation of smart materials in regenerative medicine
Judith M. Curran, Robert Stokes, Eleanore Irvine, Duncan Graham, N. A. Amro, R. G. Sanedrin, H. Jamil and John A. Hunt, Lab Chip, 2010, 10, 1662
Here we report the successful use of dip pen nanolithography as a tool for producing surfaces that can be used to control stem cell behaviour and produce homogenous populations of cells.
Carcinoma-associated fibroblasts promoted tumor spheroid invasion on a microfluidic 3D co-culture device
Tingjiao Liu, Bingcheng Lin and Jianhua Qin, Lab Chip, 2010, 10, 1671
We present a microfluidic-based 3D co-culture device to reconstruct an in vitro tumor microenvironment for investigating the effect of CAFs on cancer cell invasion in 3D matrix.
Continuous sorting of heterogeneous-sized embryoid bodies
Peter B. Lillehoj, Hideaki Tsutsui, Bahram Valamehr, Hong Wu and Chih-Ming Ho, Lab Chip, 2010, 10, 1678
We present a compact device for sorting embryoid bodies (EBs), ranging from 1–300 µm, based upon the modification of a fluid flow within a microchannel with high separation efficiencies.
Assessment of mitochondrial membrane potential using an on-chip microelectrode in a microfluidic device
Tae-Sun Lim, Antonio Dávila, Douglas C. Wallace and Peter Burke, Lab Chip, 2010, 10, 1683
An on-chip microelectrode sensor fabricated with ion-selective membranes allows non-invasive, electrochemical, in situ monitor of the mitochondrial membrane potential in a controlled microfluidic environment.
Fabrication of nanocluster silicon surface with electric discharge and the application in desorption/ionization on silicon-mass spectrometry
Niina M. Suni, Markus Haapala, Elina Färm, Emma Härkönen, Mikko Ritala, Lauri Sainiemi, Sami Franssila, Tapio Kotiaho and Risto Kostiainen, Lab Chip, 2010, 10, 1689
Atmospheric pressure microdischarge to create nanocluster silicon surface.
Mapping and manipulating temperature–concentration phase diagrams using microfluidics
eila Selimovi, Frédéric Gobeaux and Seth Fraden, Lab Chip, 2010, 10, 1696
The PhaseChip can measure phase diagrams of aqueous solutions as a function of concentration (C) and temperature (T). The chip stores 800 drops of 20 nl volume at 400 different values of C, T.
Optimized droplet-based microfluidics scheme for sol–gel reactions
Venkatachalam Chokkalingam, Boris Weidenhof, Michael Krämer, Wilhelm F. Maier, Stephan Herminghaus and Ralf Seemann, Lab Chip, 2010, 10, 1700
Silica particles with superior surface area are produced by an optimized sol–gel synthesis route where the chemicals are dispensed into droplet pairs, merged, mixed and pre-processed in the microfluidic device.
Motility enhancement of bacteria actuated microstructures using selective bacteria adhesion
Sung Jun Park, Hyeoni Bae, Joonhwuy Kim, Byungjik Lim, Jongoh Park and Sukho Park, Lab Chip, 2010, 10, 1706
The bacteria patterned to a specific site using 5% BSA significantly increase the motility of the bacteria actuated microstructure.
A microfluidic mixer with self-excited turbulent fluid motion for wide viscosity ratio applications
H. M. Xia, Z. P. Wang, Y. X. Koh and K. T. May, Lab Chip, 2010, 10, 1712
While the flow in a microfluidic device is typically laminar, which greatly impedes the mixing rate, the current micromixer design produces viscous flow instabilities to achieve global turbulent mixing for liquids with large viscosity contrasts.
An integrated microfluidic system for studying cell-microenvironmental interactions versatilely and dynamically
Wenming Liu, Li Li, Xuming Wang, Li Ren, Xueqin Wang, Jianchun Wang, Qin Tu, Xiaowen Huang and Jinyi Wang, Lab Chip, 2010, 10, 1717
We present an integrated microfluidic system for the study of cell-microenvironmental interactions, which can provide precise and efficient micromechanical manipulation for positioning operation and microenvironmental transition.
Rapid PCR amplification using a microfluidic device with integrated microwave heating and air impingement cooling
Kirsty J. Shaw, Peter T. Docker, John V. Yelland, Charlotte E. Dyer, John Greenman, Gillian M. Greenway and Stephen J. Haswell, Lab Chip, 2010, 10, 1725
An 8 GHz microwave based heating system with air impingement cooling offering rapid PCR thermal cycling with heating and cooling rates of up to 65 °C s-1 and minimal over-shooting or under-shooting (±0.1 °C).
We present the construction and operation of a microfluidic nozzle created using several standard fluidic parts available commercially.
Partial wetting gas–liquid segmented flow microreactor
S. Ali Kazemi Oskooei and David Sinton, Lab Chip, 2010, 10, 1732
A partial wetting microfluidic reactor strategy is demonstrated that effectively eliminates dispersion between liquid plugs.