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Microfluidic & nanofluidic technologies for chemistry, physics, biology, and bioengineering
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Paper
Lab Chip, 2007, 7, 829 - 834, DOI: 10.1039/b700799j
A microfluidic device based on droplet storage for screening solubility diagrams
Philippe Laval, Nicolas Lisai, Jean-Baptiste Salmon and Mathieu Joanicot
This work describes a new microfluidic device developed for the rapid screening of solubility diagrams. In several parallel channels, hundreds of nanolitre volume droplets of a given solution are first stored with a gradual variation in the solute concentration. Then, the application of a temperature gradient along these channels enables us to read directly and quantitatively phase diagrams, concentration vs. temperature. We show, using a solution of adipic acid, that we can measure ten points of the solubility curve in less than 1 hr and with only 250 µL of solution.
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