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Lab on a Chip

Microfluidic & nanofluidic technologies for chemistry, physics, biology, and bioengineering



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Paper

Lab Chip, 2008, 8, 892 - 897, DOI: 10.1039/b800370j

Protecting, patterning, and scaffolding supported lipid membranes using carbohydrate glasses

Ann E. Oliver, Eric L. Kendall, Michael C. Howland, Babak Sanii, Andrew P. Shreve and Atul N. Parikh

Disaccharides are known to protect sensitive biomolecules against stresses caused by dehydration, both in vivo and in vitro. Here we demonstrate how interfacial accumulation of trehalose can be used to (1) produce rugged supported lipid bilayers capable of near total dehydration; (2) enable spatial patterning of membrane micro-arrays; and (3) form stable bilayers on otherwise lipophobic substrates (e.g., metal transducers) thus affording protecting, patterning, and scaffolding of lipid bilayers.

Graphical abstract image for this article (ID: b800370j)