_tcm18-11405.gif )
Microfluidic & nanofluidic technologies for chemistry, physics, biology, and bioengineering
Subscribers
Non-subscribers
- Purchase article PDF [£30 + taxes]
- Purchase article PDF member offer [£5 + taxes]
Free access
Paper
Lab Chip, 2009, 9, 1449 - 1454, DOI: 10.1039/b818622g
SU-8 force sensing pillar arrays for biological measurements
Joseph C. Doll, Nahid Harjee, Nathan Klejwa, Ronald Kwon, Sarah M. Coulthard, Bryan Petzold, Miriam B. Goodman and Beth L. Pruitt
The generation and sensation of mechanical force plays a role in many dynamic biological processes, including touch sensation. This paper presents a two-axis micro strain gauge force sensor constructed from multiple layers of SU-8 and metal on quartz substrates. The sensor was designed to meet requirements for measuring tactile sensitivity and interaction forces exerted during locomotion by small organisms such as the nematode Caenorhabditis elegans. The device is transparent and compatible with light microscopes, allowing behavioral experiments to be combined with quantitative force measurements. For the first time, we have characterized the scale of interaction forces generated in wild-type C. elegans in probing and responding to their environment during locomotion. The device features sub-µN force resolution from 1 Hz to 1 kHz, >25 µN range, kHz acquisition rates and biocompatibility.
RSS feed