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Microfluidic & nanofluidic technologies for chemistry, physics, biology, and bioengineering
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Communication
Lab Chip, 2009, 9, 863 - 866, DOI: 10.1039/b821930c
Lock release lithography for 3D and composite microparticles
Ki Wan Bong, Daniel C. Pregibon and Patrick S. Doyle
We present a method called
Lock Release Lithography (LRL)
that utilizes a combination of channel topography, mask design, and pressure-induced channel deformation to form and release particles in a cycled fashion. This technique provides a means for the high-throughput production of particles with complex 3D morphologies and composite particles with spatially configurable chemistries. In this work, we demonstrate a diverse set of functional particles including those displaying heterogeneous swelling characteristics and containing functional entities such as nucleic acids, proteins and beads.
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