Issue 22, 2009
From the journal:

Lab on a Chip

Microfluidics with on-line dynamic light scattering for size measurements

Fanny Destremaut,*a   Jean-Baptiste Salmon,a   Ling Qi†b  and  Jean-Paul Chapel‡b  

* Corresponding authors

a LOF, UMR 5258 Rhodia–CNRS–Bordeaux 1, 178 avenue du Docteur Schweitzer, Pessac cedex, FRANCE
E-mail: fanny.destremaut-exterieur@eu.rhodia.com

b Complex Assembly of Soft Matter, UMI 3254 CNRS-Rhodia, Rhodia Center for Research and Technology, 350 Georges Patterson Blvd., Bristol, Pennsylvania, USA

Abstract

We present a detailed investigation on the feasibility of on-line dynamic light scattering measurements of colloidal sizes in a pressure-driven microfluidic flow. We review some theoretical arguments showing that such experiments are difficult to perform due to the Poiseuille flow that induces interferences of different Doppler shifts. Such a theoretical approach is however very useful to figure out the range of parameters where on-line size measurements are possible. We then build a dynamic light scattering setup around a microfluidic chip that enables us to estimate the size of Brownian scatterers flowing in PDMS-based microchannels, thus validating experimentally the theoretical estimations. We finally present a microfluidic chip that can mix two reactants in ≈200 ms, and allows size measurements using dynamic light scattering at about 300 ms after complete mixing. Two applications are presented: the continuous monitoring of the viscosity of a two-fluid mixture, and the electrostatic co-assembly of oppositely charged nanoparticles and block copolymers.

Graphical abstract: Microfluidics with on-line dynamic light scattering for size measurements

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/B906514H
Article type
Paper
Submitted
01 Apr 2009
Accepted
20 Aug 2009
First published
17 Sep 2009

Lab Chip, 2009,9, 3289-3296

Permissions

Request permissions

Microfluidics with on-line dynamic light scattering for size measurements

F. Destremaut, J. Salmon, L. Qi and J. Chapel, Lab Chip, 2009, 9, 3289 DOI: 10.1039/B906514H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements