Molecular BioSystems

Research interfacing chemical biology with the -omic sciences and systems biology.

About Molecular BioSystems

  • Impact factor: 3.183
  • Published monthly
  • Abstracts cited in MEDLINE             


Scope of Molecular BioSystems
Molecular BioSystems is a broad scope journal which publishes significant and high quality research at the chemistry-biology interface. Core areas of research are chemical biology, -omics sciences and systems biology.  


Chemical biology - experimental and theoretical research at the interface of chemistry and biology, covering both chemical tools for biological questions, and molecular-level understanding, control and manipulation of biological processes. Topics include:

  • Design, development and use of chemical tools to probe biological systems
  • Molecular-level structural and mechanistic studies of proteins, nucleic acids, sugars and lipids
  • Molecular-level study and control of biological processes including signal transduction, protein-protein/DNA/RNA interaction, nucleic acid replication and repair, protein folding, gene expression, intracellular signalling, biosynthesis and post-translational modifications
  • Chemical methods in biological systems, including imaging, labelling techniques, directed evolution, genetic and metabolic engineering and other chemical methods of manipulating biology to enable biological understanding or create new functions
  • Pharmacological studies which provide wider insight into biology (note that chemical biology studies specifically directed towards drug discovery are better suited to our sister journal MedChemComm).     


Omics sciences - experimental and bioinformatics research in the -omics sciences, including genomics, proteomics, transcriptomics and metabolomics. -omics studies with a focus on chemical biology are of particular interest. Topics include: 

  • Omics studies to gain mechanistic insight into biological processes (e.g. determining the mode of action of a drug, or the basis of a particular phenotype, such as drought tolerance).
  • Omics studies for clinical applications, with validation (e.g. finding biomarkers for diagnostics or potential new drug targets).
  • Omics studies looking at the sub-cellular make-up of cells (e.g. the subcellular localisation of certain proteins or post-translational modifications, and new imaging techniques).
  • Studies presenting new tools to support omics studies, including new spectroscopic/chromatographic techniques, chip-based/array technologies and new classification/data analysis techniques     


Systems biology - modelling, simulation and analysis of the components and interactions in complex biological systems, including cells, genes and metabolic or signalling networks. Topics include:

  • Mathematical and biological simulation and modelling 
  • Data mining, transformations, integration and quantitative analysis techniques
  • High-throughput technologies
  • Software, tools, databases and methodologies for simulation and modelling

Who should read Molecular BioSystems?


Researchers, from industry or academia, drawing on the fundamental disciplines and technologies of chemistry and biology, with the aim of providing insight, at a molecular level, into the world of life sciences. 

Thus the journal will appeal to a wide variety of researchers, but particularly to: 

chemical biologists; biological chemists; biochemists; molecular and structural biologists; drug discovery scientists; protein chemists; bio- and cheminformaticians; organic, biological, analytical, physical and inorganic chemists and materials scientists.

Molecular BioSystems

Molecular BioSystems scope, standards and article types

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