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Research at the interface between chemistry and the -omic sciences and systems biology.
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Mol. BioSyst., 2005, 1, 260 - 264, DOI: 10.1039/b503302k
Nucleoside phosphocholine amphiphile for in vitro DNA transfection
Louis Moreau, Philippe Barthélémy, Yougen Li, Dan Luo, Carla A. H. Prata and Mark W. Grinstaff
A new transfection reagent based on nucleoside phosphocholine amphiphile leading to high transfection efficacy and low cytotoxicity is described. TEM, ethidium bromide displacement assays, agarose gel electrophoresis and SAXS studies support the formation of lipoplexes for the transfection of CHO cells.
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