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Molecular BioSystems

Research at the interface between chemistry and the -omic sciences and systems biology.



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Communication

Mol. BioSyst., 2008, 4, 518 - 520, DOI: 10.1039/b719423d

A simple solid-phase synthesis of the ubiquitous bacterial signaling molecule, c-di-GMP and analogues

Irene Kiburu, Andrew Shurer, Lei Yan and Herman O. Sintim

Cyclic-di-guanylate (c-di-GMP) has emerged as a general and important signaling molecule uniquely present in bacteria: herein we provide a simple solid-phase synthesis of c-di-GMP using an automated DNA synthesizer for the majority of the synthesis.

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