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Research at the interface between chemistry and the -omic sciences and systems biology.
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Paper
Mol. BioSyst., 2008, 4, 532 - 541, DOI: 10.1039/b719782a
Acid cleavable PEG-lipids for applications in a ternary gene delivery vector
John B. Wong, Stephanie Grosse, Alethea B. Tabor, Stephen L. Hart and Helen C. Hailes
A novel class of pH-sensitive PEG lipids bearing acid-cleavable acetal linkages and short PEG chains have been synthesised and used in ternary vector formulations. The cleavage pH was influenced by structural components including the terminal PEG moiety and spacer length.
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