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Molecular BioSystems

Research at the interface between chemistry and the -omic sciences and systems biology.



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Paper

Mol. BioSyst., 2008, 4, 558 - 561, DOI: 10.1039/b802199f

Chemical site-selective prenylation of proteins

David P. Gamblin, Sander van Kasteren, Gonçalo J. L. Bernardes, Justin M. Chalker, Neil J. Oldham, Antony J. Fairbanks and Benjamin G. Davis

A direct thionation procedure allows conversion of allylic alcohols into the corresponding thiols, the products of which are immediately compatible with one-pot site-selective selenenyl sulfide mediated protein conjugation.

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