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Molecular BioSystems

Research at the interface between chemistry and the -omic sciences and systems biology.



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Communication

Mol. BioSyst., 2009, 5, 1306 - 1310, DOI: 10.1039/b900880b

In vivo siRNA delivery with dendritic poly(L-lysine) for the treatment of hypercholesterolemia

Kazuto Watanabe, Mariko Harada-Shiba, Akira Suzuki, Risa Gokuden, Ryohsuke Kurihara, Yusuke Sugao, Takeshi Mori, Yoshiki Katayama and Takuro Niidome

Intravenous delivery of apolipoprotein B-specific siRNA with a sixth-generation of dendritic poly(L-lysine) (KG6) resulted in siRNA-mediated knockdown of ApoB in healthy C57BL/6 mice without hepatotoxicity, and with a significant reduction of serum low-density lipoprotein cholesterol in apolipoprotein E-deficient mice.

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