Issue 10, 2009
From the journal:

Molecular BioSystems

Fluorine—a new element in the design of membrane-active peptides

E. Neil G. Marsh,*abc   Benjamin C. Buera  and  Ayyalusamy Ramamoorthy*ab  

* Corresponding authors

a Department of Chemistry, University of Michigan, Ann Arbor, USA
E-mail: nmarsh@umich.edu, ramamoor@umich.edu

b Department of Biophysics, University of Michigan, Ann Arbor, USA

c Department of Biological Chemistry, University of Michigan, Ann Arbor, USA

Abstract

Antimicrobial peptides (also known as genetically encoded peptide antibiotics) are a diverse class of short cationic amphipathic polypeptides that exhibit a broad-spectrum of antimicrobial activities by selectively disrupting the bacterial cell membrane. In this review article, we present the use of fluorinated amino acids in the design of antimicrobial peptides and other membrane-active peptides.

Graphical abstract: Fluorine—a new element in the design of membrane-active peptides

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Article information

DOI
https://doi.org/10.1039/B909864J
Article type
Review Article
Submitted
19 May 2009
Accepted
02 Jul 2009
First published
28 Jul 2009

Mol. BioSyst., 2009,5, 1143-1147

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Fluorine—a new element in the design of membrane-active peptides

E. N. G. Marsh, B. C. Buer and A. Ramamoorthy, Mol. BioSyst., 2009, 5, 1143 DOI: 10.1039/B909864J

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