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ISM 09 prize winners
19 June 2009
Congratulations to the poster prize winners at the 2009 International Symposium on Metallomics, co-badged by Metallomics
Issue 7 2009 Chemical Biology now published
16 June 2009
Drawing together coverage from all RSC publications, providing an overview of the latest developments in chemical biology
Submit your article from ISM 2009!
01 June 2009
We invite you to submit your work presented at the 2009 International Symposium on Metallomics for publication in a themed issue of Metallomics.
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Previous news from Metallomics
Contents list for Metallomics, issue 3, 2009
Front cover
Metallomics, 2009, 1, 177
DOI: 10.1039/b908469j
Inside front cover
Metallomics, 2009, 1, 178
DOI: 10.1039/b908470n
Contents and Chemical Biology
Metallomics, 2009, 1, 179
DOI: 10.1039/b908471c
Editorials
Metallomics scope
Metallomics, 2009, 1, 189
DOI: 10.1039/b908181j
Changing the face of scientific publishing
Metallomics, 2009, 1, 190
DOI: 10.1039/b906424a
InChIs, open standards and data collections—Richard Kidd describes how RSC Publishing is leading the way in technical innovation.
Minireview
Advances in developing tris(8-quinolinolato)gallium(III) as an anticancer drug: critical appraisal and prospects
Andrei R. Timerbaev,
Metallomics, 2009, 1, 193
DOI: 10.1039/b902861g
Enhanced HTML article available
This minireview highlights advances in the development of one of the most promising gallium-based drugs to fight cancer and a critical point of view on the rational pathway to follow in the discovery of more effective anticancer weaponry.
Perspective
Zinc and tetrathiomolybdate for the treatment of Wilson
s disease and the potential efficacy of anticopper therapy in a wide variety of diseases
George J. Brewer,
Metallomics, 2009, 1, 199
DOI: 10.1039/b901614g Enhanced HTML article available
Two new anticopper drugs developed by the author, zinc and tetrathiomolybdate, effective in Wilsons disease, are discussed. Lowering copper levels with tetrathiomolybdate has antifibrotic, antiinflammatory and anti-autoimmune efficacy.
Critical Review
Interplay of metal ions and urease
Eric L. Carter, Nicholas Flugga, Jodi L. Boer, Scott B. Mulrooney and Robert P. Hausinger,
Metallomics, 2009, 1, 207
DOI: 10.1039/b903311d Enhanced HTML article available
Cells use an intricate assembly system to create the dinuclear nickel active site of urease that catalyzes the deceptively simple decomposition of urea.
Tutorial Review
Epigenetics in metal carcinogenesis: nickel, arsenic, chromium and cadmium
Adriana Arita and Max Costa,
Metallomics, 2009, 1, 222
DOI: 10.1039/b903049b Enhanced HTML article available
This tutorial review discusses the current evidence for the possible epigenetic mechanisms for nickel, arsenite, chromium and cadmium and how these changes may play a role in their metal-induced carcinogenicity.
Papers
Independent metal-binding features of recombinant metallothioneins convergently draw a step gradation between Zn- and Cu-thioneins
Roger Bofill, Mercè Capdevila and Sílvia Atrian,
Metallomics, 2009, 1, 229
DOI: 10.1039/b904953c Enhanced HTML article available
Consideration of the in vivo and in vitro metal-binding trends of ca. 20 recombinant metallothioneins from divergent organisms coincides in a new classification: a stepwise gradation between Zn- and Cu-thioneins where the intermediate positions in the list are polyvalent MTs of merging Zn-/Cu-character.
Characterization of metal–peptide complexes in feed supplements of essential trace elements
Alexandros Yiannikouris, Cathal Connolly, Ronan Power and Ryszard Lobinski,
Metallomics, 2009, 1, 235
DOI: 10.1039/b901406c Enhanced HTML article available
Two dimensional parallel ICP MS and ESI MS/MS approach for the fine discrimination and characterization of the metal–peptide complexes formed through chelation on a particular source of proteinates.
Hijacking transferrin bound iron: protein–receptor interactions involved in iron transport in N. gonorrhoeae
Claire J. Parker Siburt, Petra L. Roulhac, Katherine D. Weaver, Jennifer M. Noto, Timothy A. Mietzner, Cynthia N. Cornelissen, Michael C. Fitzgerald and Alvin L. Crumbliss,
Metallomics, 2009, 1, 249
DOI: 10.1039/b902860a Enhanced HTML article available
Differential binding of apo- and holo-FbpA with TbpA was established for the first time by SUPREX. Iron stripping from holo-Tf by either TbpA or TbpB was observed and a detailed model for iron transport is proposed.
Unusual flexibility of distal and proximal histidine residues in the haem pocket of Drosophila melanogaster haemoglobin
Anda Iulia Ioanitescu, Sabine Van Doorslaer, Sylvia Dewilde and Luc Moens,
Metallomics, 2009, 1, 256
DOI: 10.1039/b902059b Enhanced HTML article available
A combined resonance Raman, continuous-wave and pulsed electron paramagnetic resonance study reveals a significant flexibility of the proximal and distal histidine ligands of the haem iron in Drosophila melanogaster haemoglobin.
Back matter
Metallomics, 2009, 1, 265
DOI: 10.1039/b908472j
Back cover
Metallomics, 2009, 1, 267
DOI: 10.1039/b908473h
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