Paper

New J. Chem., 2009, 33, 1888 - 1893, DOI: 10.1039/b906441a

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A selective fluorescent sensor for imaging Cu²⁺ in living cells

Lijuan Jiao, Jilong Li, Shengzhou Zhang, Chao Wei, Erhong Hao and M. Graça H. Vicente

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Copper ion is a biochemically essential yet toxic metal ion, connected to serious neurodegenerative diseases, and also has been identified as an environmental pollutant. For the effective detection of Cu²⁺ in biological and environmental systems, we have developed a new membrane-permeable Cu²⁺-selective water-soluble BODIPY 1, which was synthesized by nucleophilic disubstitution of novel 3,5-diiodo-BODIPY 4 with N,N-bis(2-hydroxyethyl)amines. BODIPY 1 shows a highly sensitive and selective fluorescence response to Cu²⁺ in aqueous solution. Fluorescence image experiments establish that 1 can be used to monitor intracellular Cu²⁺ within living cells.

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