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Latest News
Meet the board - Hal Kohn
26 June 2008
The NPR editorial board member tells Joanne Thomson about investigating the unknown and the joy experienced when its secrets are revealed
New journal announced: Integrative Biology
12 June 2008
January 2009 will see Integrative Biology: Quantitative biosciences from nano to macro, launched by RSC Publishing
Issue 3 of NPR now online
23 May 2008
The latest issue of Natural Product Reports is now available online
NPR news archive
Contents list for Natural Product Reports, issue 3, 2008
Front cover
Nat. Prod. Rep., 2008, 25, 433
DOI: 10.1039/b807814a
Contents and Chemical Biology
Nat. Prod. Rep., 2008, 25, 435
DOI: 10.1039/b807815g
Hot off the Press Article
Hot off the press
Robert A. Hill and Andrew Sutherland,
Nat. Prod. Rep., 2008, 25, 443
DOI: 10.1039/b806751c
A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as echinopine A from the roots of Echinops spinosus.
Highlight
Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria
Hui Hong, Caroline Demangel, Sacha J. Pidot, Peter F. Leadlay and Tim Stinear,
Nat. Prod. Rep., 2008, 25, 447
DOI: 10.1039/b803101k
Mycolactone structural variants, produced by Mycobacterium ulcerans and related mycobacteria, are caused by rearrangements among the highly homologous domains and modules within the MlsB polyketide megasynthase, that in turn alter the immunosuppressive and cytotoxic potency of these natural products.
Review Articles
Biofabrication of biosilica-glass by living organisms
Heinz C. Schröder, Xiaohong Wang, Wolfgang Tremel, Hiroshi Ushijima and Werner E. G. Müller,
Nat. Prod. Rep., 2008, 25, 455
DOI: 10.1039/b612515h
Much progress has been made in recent years in elucidation of the molecular mechanism of biosilicification. This review summarizes the present state of knowledge on biosilica formation in sponges, diatoms and other silicifying organisms.
Natural products to drugs: natural product-derived compounds in clinical trials
Mark S. Butler,
Nat. Prod. Rep., 2008, 25, 475
DOI: 10.1039/b514294f
This review covers NP-derived compounds that are being evaluated in clinical trials or are in registration at the end of 2007, as well as compounds that have been marketed or discontinued since 2005, new NP-templates and late-stage development candidates.
Natural product isolation
Otto Sticher,
Nat. Prod. Rep., 2008, 25, 517
DOI: 10.1039/b700306b
This review deals with sample preparation and purification, recent extraction techniques used for natural product separation, liquid–solid and liquid–liquid isolation techniques, as well as multi-step chromatographic operations.
Flavonoids and their glycosides, including anthocyanins
Nigel C. Veitch and Renée J. Grayer,
Nat. Prod. Rep., 2008, 25, 555
DOI: 10.1039/b718040n
Covering research published on flavonoids between 2004 and 2006, more than 600 new aglycones and glycosides are described, comprising flavones, flavonols, chalcones, dihydrochalcones, aurones, flavanones, dihydroflavonols, anthocyanidins and anthocyanins
Terpenoid alkaloids of the Buxaceae family with potential biological importance
Krishna P. Devkota, Bruno N. Lenta, Patrice A. Fokou and Norbert Sewald,
Nat. Prod. Rep., 2008, 25, 612
DOI: 10.1039/b704958g
This review gives a comprehensive overview of the isolation, structure elucidation, biosynthesis and biological activity of terpenoid alkaloids from plants of the family Buxaceae.
Back matter
Nat. Prod. Rep., 2008, 25, 631
DOI: 10.1039/b807816p
Back cover
Nat. Prod. Rep., 2008, 25, 635
DOI: 10.1039/b807817n
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