Issue 4 features a Highlight article by Christopher Walsh, Sylvie Garneau-Tsodikova and Annaleise R. Howard-Jones on Biological formation of pyrroles.¹ Highlight articles, a new development in NPR for 2006, are generally short articles reviewing recent work and bringing into focus topics of both general and specialist interest. These concise works will also cover emerging areas within natural products chemistry. Highlights are launched in response to the need of the scientific community for up-to-the-minute information on the latest research. Issue 1 2006 saw the first Highlight published, written by Tad Begley on cofactor biosynthesis.²

Featured on the cover of this issue is an unidentified ascidian, photographed at the Great Barrier Reef in December 2004 by Anke Kleuter, Australian Institute of Marine Sciences.