_tcm18-11415.gif )
An international journal for the quickest publication of high-quality research covering the breadth of synthetic, physical and biomolecular organic chemistry.
Cover Gallery
The cover shows the 13C NMR traces of enantioenriched propargylic fluorides in the chiral liquid crystalline solvent poly(y-benzylL-glutamate) (PBLG) and chloroform. The data revealed that the electrophilic anti SE2' fluorination of allenylsilanes proceeds with highly efficient transfer of chirality. Cover illustration produced by Dr Karl Harrison (Chemistry Department, University of Oxford).
DOI: 10.1039/B803888K
Metal amidinates can be protonated by the RE-H bonds, leading to catalytic formation of various amidine derivatives from RE-H and carbodiimides.
DOI: 10.1039/b806494f
A number of methodologies allow for the enantioselective functionalisation of [2.2]paracyclophane to give valuable planar chiral molecules.
DOI: 10.1039/b800698a
The N?O-acylshift in threonine-containing phosphopeptides has been investigated and characterised by HPLC-MS and NMR-methods. Phosphopeptides are important for the regulation of protein-protein interactions in signal transduction. The background shows the binding site of the human insulin receptor.
DOI: 10.1039/b718568e
Issue 8, 2008 inside front cover
The natural product oroidin, isolated from marine sponges such as Agelas clathrodes (pictured), provides a unique scaffold for small molecules that inhibit biofilm formation and disperse established Pseudomonas aeruginosa biofilms. Image courtesy of Marc M. Ellis / H2O Pictures.
DOI: 10.1039/b804736g
Ate complex formation between boranes and Si-substituted ylides is reversible, and this affects stereoselectivity.
DOI: 10.1039/B718496D
The image shows the nonribosomal peptide synthetase assembly line which is responsible for the biosynthesis of the lipopeptide antibiotic (CDA) and in the background is a microscope image of an antibiotic producing streptomyces culture.
DOI: 10.1039/B718766C
Issue 6, 2008 inside front cover
In this Perspective, G. Mugesh and B. K. Sarma describe the effect of various thiol cofactors on the biological activity of three major mammalian selenoenzymes, namely glutathione peroxidase, iodothyronine deiodinase and thioredoxin reductase.
DOI: 10.1039/b802984a
Reaction of a free-base porphyrin with iodine acetate gives a radical cation intermediate that can combine with an acetate anion leading to the acetoxylated product or an iodine radical to form the iodo-substituted porphyrin.
DOI: 10.1039/B718542A
Colonies of Pseudomonas aeruginosa grown on Columbia agar containing 50 mg/L 7-N-(?-alanyl)amino-1-pentylphenoxazin-3-one trifluoroacetate after 48 hours incubation at 37 °C (picture courtesy of Larissa Laine, Freeman Hospital, Newcastle upon Tyne, UK)
DOI: 10.1039/B716978G
Both enantiomers of 2-amino-1-phenylethanol (2-APE) were resolved by the use of dehydroabietic acid (DAA), a natural chiral acid, by switching resolving solvents. The crystal structures of both diastereomeric salts, (R)-APE/DAA and (S)-APE/DAA, showed that EtOH molecule was only involved in (R)-APE/DAA to complete the necessary H-bond network.
DOI: 10.1039/b717071h
Issue 3, 2008 Inside front cover
Conformationally rigid oligomers whose facially amphiphilic conformations can be exploited to generate a novel class of compounds that interacts with phospholipid bilayers and shows promise to be potent antimicrobial agents. Dr. Karen Lienkamp and Jeffrey M. Dabkowski are gratefully acknowledged for making the image
DOI: 10.1039/b800425k
The cover picture illustrates recent challenges in aminoglycosides research towards obtaining novel molecular designs as effective antibiotics (selectively targeting bacterial cells) and agents for treatment of human genetic disorders (with increased selectivity to human cells).
DOI: 10.1039/b712690p
High resolution gel-phase proton NMR spectroscopy is a versatile tool for monitoring the thermodynamically controlled self-assembly of polystyrene-bound rotaxanes from their component parts in the surrounding solution phase.
DOI: 10.1039/b719227b
In recent years a remarkable interest in bioorganometallics, such as metallo-nucleosides, has emerged. The cover focuses on the crystal structure of cobalt-modified 5-alkynyl-2'-deoxyuridine, which highlights the antitumor activity of hexacarbonyl dicobalt alkynes against breast cancer cells. Cover Art by Tomasz Sniady.
DOI: 10.1039/b713371e
Not much fits in between sheets of graphite, but there's enough room to accommodate nanometer clusters of nickel. And with reaction partners in the surrounding solution ready to couple as the sheets slide and eventually expose the metal, heterogeneous catalysis can occur to make either C-C or C-H bonds.
DOI: 10.1039/b718411p
RSS feed