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An international journal for the quickest publication of high-quality research covering the breadth of synthetic, physical and biomolecular organic chemistry.
OBC cover gallery 2006
Previous OBC covers are available for browsing here
Cover Gallery
The image depicts the progress made in moving from the natural product artemisinin to a viable fully synthetic endoperoxide drug with superior antimalarial activity. The backdrop is a photograph of the plant Artemisia annua (Sweet wormwood) from which artemisinin is extracted.
DOI: 10.1039/b613565j
Examples of fluorescent DNA base replacements with diverse applications such as monitoring DNA structure and dynamics, detection of metal ions, or generation of novel oligomeric fluorophores
DOI: 10.1039/b612284c
Evolution of Wolff's 1902 discovery of functional group migration upon thermal loss of N2 from a diazoketone, in 2006, now includes the unprecedented formation of ring-contracted porphyrins bearing nucleophilic substrate addition as examples of potential biochemical labeling reagents.
DOI: 10.1039/b612776m
Regio-and stereoselective C-X and C-C bond formation from unactivated C-H bonds offers an emerging opportunity for asymmetric catalysis and synthesis.
DOI: 10.1039/b615204j
The first example of a cis-1,3-disubstituted cyclobutane-containing receptor has been synthesized and is demonstrated to have high affinity for bacterial lipid A.
DOI: 10.1039/b610727c
A macromolecular rather than a multivalency effect is considered for the mechanism of bacterial adhesion.
DOI: 10.1039/b614469c
The conformationally mobile cationic arms of a calix[8]arene-lysine derivative completely surround heparin in an "octopus-like" structure allowing an exceptional complexing performance.
DOI: 10.1039/b608887b
Treatment of leukaemia cells with biphenyl and related analogues of Oxamflatin led to significant inhibition of histone deacetylase and decreases in cell growth and proliferation.
DOI: 10.1039/b613719a
The front cover reveals several of the SmI2 mediated reactions developed at the University of Aarhus hovering over a satellite picture of Denmark (obtained from the Danish Meteorological Institute). Images of the university are shown in the four corners.
DOI: 10.1039/b608028f
Electronmicroscopic image of helical ribbons even progressing to closed tubes formed by a beta-peptidosulfonamide-peptide hybrid showed in the lens view of the red enlarged ribbon.
DOI: 10.1039/b612939k
Atomic force microscope image (800x800 nm) showing artificial 2D matrix self-assembled from DNA nanostructures (long rails) and antibody proteins (ladder rungs between rails). The dimerized single-chain antibody was selected for binding to a specific stem-loop aptamer displayed many times on the DNA nanostructures. Image created by Hanying Li.
DOI: 10.1039/b606391h
Researchers used a combinatorial modular approach to self-assemble DNA tiles into simple shapes of DNA nanostructures, such as a square and a chair, by varying the connectivity and position of different DNA tiles.
DOI: 10.1039/b611869k
The 3-D representation of the Hirshfeld surface for the ethanol modification of L-alanine-L-tyrosine-L-alanine calculated from experimental charge density, showing the site and strength of intermolecular interactions. The image was generated with MOLISO (A Program for Color Mapped Isosurfaces) written by Ch.B. Hübschle, Free University of Berlin.
DOI: 10.1039/b607744g
Interphase HeLa cells treated with a-aminoalkylated conjugated nitroalkenes depolymerized cellular microtubules. Shown are microtubules (green) stained with antibody against a-tubulin and chromosomes (blue) stained with 4,6-diamidino-2-phenylindole (DAPI). Normal interphase cells are shown at the top and nitroalkene treated cells, 10 mM on the bottom left and 20 mM on the right.
DOI: 10.1039/b611182n
An improvised board-and-stick model of rigid-rod ¼-stack architecture with photosynthetic activity in lipid bilayers that was made ad hoc during research described by Bhosale et al.
DOI: 10.1039/b606487f
The chemistry in thyroid glands and the effect of anti-thyroid drugs on thyroid hormone synthesis and metabolism is illustrated in the cover picture.
DOI: 10.1039/B604060H
The images show the lowest energy docked conformations of two alpha-ketoesters into the active site of SSCR, which reflect reversed enantiopreference of enzymatic reduction of aromatic and aliphatic alpha-ketoesters.
DOI: 10.1039/B606001C
Copper(II) salt-catalysed 1,3-dipolar cycloaddition can be as beautiful as sunset in the North Pacific.
DOI: 10.1039/b608818j
Oxygen and alcohol substrate dissolved in supercritical carbon dioxide diffuse through fluorinated organosilica matrix to entrapped Ru catalyst where dehydrogenation takes place and the product is extracted by scCO2 itself. Image courtesy of Massimo Carraro.
DOI: 10.1039/b604663k
Another orange revolution! Stereoselective reduction of prochiral ketones by carrot roots emerges as a powerful tool. The artwork was created by Stephane Bourg.
DOI: 10.1039/b605233a
An algal bloom at a beach north of Auckland, New Zealand. Photograph taken by Miriam Godfrey.
DOI: 10.1039/B604334H
The artwork shows the two main catalytic processes known to date for the synthesis of enantioenriched fluorinated compounds: transition metal catalysis (left) and organocatalysis (right).
DOI: 10.1039/b606645n
Polarized optical microscope image of bundles of organic nanotubes composed of stacking cyclic beta-amino acids. Coloring with a sensitive tint plate shows a larger refractive index along the bundles than the diameter due to the regular molecular stacking.
DOI: 10.1039/B600407e
5-Methylcytosine was distinguished from cytosine using the large difference of their osmium oxidation rates, and this reaction was applied to detection of the cytosine methylation status at a specific site of DNA.
DOI: 10.1039/B600401F
Schematic of cell-cell communication in Gram-positive bacteria, or quorum sensing, and its interception with non-native ligands. Graphic design: Betsy True (Madison, WI). Background: SEM of Staphylococcus aureus (X8500); courtesy of Visuals Unlimited.
DOI: 10.1039/B517681F
Novel retinal Schiff bases with conformational restraints have been prepared and investigated for their intrinsic chromophoric properties in the gas phase. The studies reveal that in the absence of protein interactions we would not be able to perceive blue light. New reference values for defining the so-called "opsin shift" are provided.
DOI: 10.1039/b604249j
Photo-thermal switching of chemical properties. On-off switching of intramolecular hydrogen bond by photo-thermal isomerization cycle provides a new approach for the active controlling of chemical properties of functional molecules.
DOI: 10.1039/B516049A
The cover image shows a chemically synthesized model polymer for lignin which is one of the major components in wood cell wall.
DOI: 10.1039/b603548p
Enzymes act as logic gates that perform AND and InhibAND operations.
DOI: 10.1039/b518205k
Fascaplysin in the active site of the homology model of CDK4 showing the double hydrogen bond with Val 96.
DOI: 10.1039/b518019h
The X-ray crystal structure of secoisolariciresinol dehydrogenase, which forms matairesinol. The latter compound is an important precursor of the anticancer plant lignan podophyllotoxin, which in turn is one of the very few plant compounds actively widely used for cancer treatment. The picture of the flower is of Podophyllum peltatum.
DOI: 10.1039/B601855F
In the background, the 3-D structure of the monoamine oxidase (MAO) is displayed in newcartoon style. The front view is the potential energy profile for the benzyl amine oxidation of flavin in the MAO, highlighting the 3-D view of transition state which shows the proton transfer from benzyl amine a-C to flavin N5. The image was generated by VMD software: W. Humphrey et al. J. Mol. Graphics, 1996, 14, 33
DOI: 10.1039/b511350d
The image shows conformations calculated for a novel class of octaterpene tetracarboxylic acid, which is responsible for naphthenate deposition in crude oil processing.
DOI: 10.1039/b601225f
Molecularly imprinted polymers selective for dopamine were prepared by covalent imprinting using disulfide and cyclic boronic diester linkage, which is cleaved and oxidized to yield dopamine binding sites containing non-covalent boronic acid and sulfoxide recognition groups.
DOI: 10.1039/b514432a
Control of aggregation-disaggregation of fullerene derivatives
DOI: 10.1039/b600448m
Cationic liposome-mediated cytosolic delivery of genetic material.
DOI: 10.1039/b514532e
An artist's impression of a one-pot HALEX/Sonogashira recipe that enables the 'domino' reaction of aryl chlorides to biaryls. This novel concept uses heterogeneous Pd/C as the catalyst, giving easy access to a variety of inexpensive cross-coupling substrates.
DOI: 10.1039/b513450a
A visualisation of the mechanism of an organocatalytic enantioselective C-C bond forming reaction, mediated by a chiral chincona alkaloid.
DOI: 10.1039/b517044n
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