Perspective and outside front cover

Shinji Yamada from Ochanomizu University, Japan shows recent examples of how intramolecular cation-pi interactions can control conformation and selectivity in organic reactions. 

Inside front cover 

Barry Potter from the University of Bath, UK, and colleagues describe the synthesis and in vitro activity of potent dual aromatase-sulfatase inhibitors; compounds which can inhibit two key processes in the development of breast cancer. 

Emerging Area 

Molecules designed to mimic the action of naturally occurring bio-active peptides have the potential to provide new therapies for diseases. Patrick Perlmutter from Monash University, Australia and colleagues show how the substitution of an ?-amino acid with a ?-amino acid can help address some of the challenges faced in designing stable and effective peptidomimetics. 

Perspective

Nicole Steinmetz and David Evans from the John Innes Centre, UK describe how plant viruses are being used as templates and building blocks in bionanoscience applications. 

Hot article 

Jing Zhu and David Smithrud from the University of Cincinnati, US show how host-rotaxanes can be used as model proteins to favourably affect the entropy when binding guest molecules.