Perspective and outside front cover 
Sei-ichi Nishimoto from Kyoto University, Japan, and colleagues discuss recent research into the molecular design of drugs and imaging probes for use in cancer therapy, specifically those which target tumor-specific microenvironments such as angiogenesis and hypoxia. 

Emerging Area 
The chemistry of yoctowells - tiny vessels made up of porphyrin and diamido bolaamphiphile molecules on a smooth surface - which have the potential to act as tiny chemical reactors or sensors for use in chemistry, molecular biology and biochemistry, is described by Sheshanath Bhosale and Steven Langford from Monash University, Australia. 

Inside front cover 
Toshihiko Imato and colleagues from Kyushu University, Japan, report the design and development of a swallow-tailed perylene derivative for the detection of lipid hydroperoxides, showing that it can be applied to the imaging of lipid hydroperoxides in living cells.