The enantioselective Diels-Alder reaction is one of the most important reactions for the synthesis of complex molecules. It provides access to chiral six-membered carbocyclic compounds containing up to four stereogenic centers in a single step. In this issue's Perspective, Juan Shen and Choon-Hong Tan from the National University of Singapore describe several cases of chiral Brønsted-acid and Brønsted-base catalyzed Diels-Alder reactions, providing an overview of this rapidly growing field. 

This issue's cover was provided by Peter Wipf at the University of Pittsburgh and colleagues. In their paper they describe the computational design, synthesis and biological evaluation of quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B.