Perspective and outside front cover: 

The cover picture illustrates recent challenges in aminoglycosides research towards obtaining novel molecular designs as effective antibiotics (selectively targeting bacterial cells) and agents for treatment of human genetic disorders (with increased selectivity to human cells). 

Perspective: 

[1,3] Rearrangements have a long history that predates the first report of the related Claisen rearrangement. This review describes early developments in the field and discusses mechanism with a focus on stereoselective rearrangements.

Emerging Area: 

Recent applications of dynamic combinatorial libraries (DCLs) as biosensors or for the discovery of protein ligands or smart materials have demonstrated that dynamic combinatorial chemistry is not simply an elegant concept limited to model systems.

Inside front cover: 

High resolution gel-phase proton NMR spectroscopy is a versatile tool for monitoring the thermodynamically controlled self-assembly of polystyrene-bound rotaxanes from their component parts in the surrounding solution phase.

Hot article: 

New sensors for reactive oxygen species reveal the importance of ring substitution on sensing efficiencies.