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An international journal for the quickest publication of high-quality research covering the breadth of synthetic, physical and biomolecular organic chemistry.
On the Front Cover of Issue 21
Bicyclic 2-pyridones act as anti-adhesive agents, blocking the complex molecular machinery of pilus biogenesis by binding the periplasmic chaperone PapD. They have been designed to target the invariant active site residues R8 and K112 in chaperones, which are key-proteins in pilus assembly. The work was carried out by Fredrik Almqvist and co-workers at Umeå University, Sweden.
C-Terminal properties are important for ring-fused 2-pyridones that interfere with the chaperone function in uropathogenic E. coli
Veronica Åberg, Mattias Hedenström, Jerome S. Pinkner, S. J. Hultgren and Fredrik Almqvist, Org. Biomol. Chem., 2005, 3, 3886
DOI: 10.1039/b509376g
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