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OBC Hot Article Archive 2005
The stereoselective synthesis of aziridine analogues of diaminopimelic acid (DAP) and their interaction with dap epimerase
Christopher M. Diaper, Andrew Sutherland, Bindu Pillai, Michael N. G. James, Paul Semchuk, John S. Blanchard and John C. Vederas, Org. Biomol. Chem., 2005, 3, 4402
DOI: 10.1039/b513409a
Asymmetric hydrogenation of aromatic compounds
Frank Glorius, Org. Biomol. Chem., 2005, 3, 4171
DOI: 10.1039/b512139f
Oligo- and poly-nucleotides: 50 years of chemical synthesis
Colin B. Reese, Org. Biomol. Chem., 2005, 3, 3851
DOI: 10.1039/b510458k
Directing the secondary structure of polypeptides at will: from helices to amyloids and back again?
Kevin Pagel, Toni Vagt and Beate Koksch, Org. Biomol. Chem., 2005, 3, 3843
DOI: 10.1039/b510098d
Synthetic mimics of mammalian cell surface receptors: prosthetic molecules that augment living cells
Blake R. Peterson, Org. Biomol. Chem., 2005, 3, 3607
DOI: 10.1039/b509866a
Control of rotor motion in a light-driven molecular motor: towards a molecular gearbox
Matthijs K. J. ter Wiel, Richard A. van Delden, Auke Meetsma and Ben L. Feringa, Org. Biomol. Chem., 2005, 3, 4071
DOI: 10.1039/b510641a
DNA-programmed assembly of nanostructures
Kurt V. Gothelf and Thomas H. LaBean, Org. Biomol. Chem., 2005, 3, 4023
DOI: 10.1039/b510551j
The synthesis and directed ortho-lithiation of 4-tert-butylsulfinyl[2.2]paracyclophane
Peter B. Hitchcock, Gareth J. Rowlands and Richard J. Seacome, Org. Biomol. Chem., 2005, 3, 3873
DOI: 10.1039/b509994c
Fourfold tetraurea calix[4]arenes—potential cores for the formation of self-assembled dendrimers
Yuliya Rudzevich, Karl Fischer, Manfred Schmidt and Volker Böhmer, Org. Biomol. Chem., 2005, 3, 3916
DOI: 10.1039/b509948j
Palladium catalysed aryl amination reactions in supercritical carbon dioxide
Catherine J. Smith, Melanie W. S. Tsang, Andrew B. Holmes, Rick L. Danheiser and Jefferson W. Tester, Org. Biomol. Chem., 2005, 3, 3767
DOI: 10.1039/b509345g
Evaluation of a new linker system cleaved using samarium(II) iodide. Application in the solid phase synthesis of carbonyl compounds
Fiona McKerlie, Iain M. Rudkin, Graham Wynne and David J. Procter, Org. Biomol. Chem., 2005, 3, 2805
DOI: 10.1039/b506294b
Two-stage enzyme mediated drug release from LMWG hydrogels
Kjeld J. C. van Bommel, Marc C. A. Stuart, Ben L. Feringa and Jan van Esch, Org. Biomol. Chem., 2005, 3, 2917
DOI: 10.1039/b507157g
One-pot multi-step synthesis: a challenge spawning innovation
Steven J. Broadwater, Shoshannah L. Roth, Kristin E. Price, Muris Koba
lija and D. Tyler McQuade, Org. Biomol. Chem., 2005, 3, 2899
DOI: 10.1039/b506621m
A new reactivity pattern for vinyl bromides: cine-substitution via palladium catalysed C–N coupling/Michael addition reactions
Michael C. Willis, Jay Chauhan and William G. Whittingham, Org. Biomol. Chem., 2005, 3, 3094
DOI: 10.1039/b508464d
Efficient synthesis of methyl lycotetraoside, the tetrasaccharide constituent of the tomato defence glycoalkaloid 
-tomatine
Nigel A. Jones, Sergey A. Nepogodiev and Robert A. Field, Org. Biomol. Chem., 2005, 3, 3201
DOI: 10.1039/b508752j
Structure–activity relationships, kinetics, selectivity, and mechanistic studies of synthetic hydraphile channels in bacterial and mammalian cells
W. Matthew Leevy, Seth T. Gammon, Tatiana Levchenko, David D. Daranciang, Oscar Murillo, Vladimir Torchilin, David Piwnica-Worms, James E. Huettner and George W. Gokel, Org. Biomol. Chem., 2005, 3, 3544
DOI: 10.1039/b508157b
C-Terminal properties are important for ring-fused 2-pyridones that interfere with the chaperone function in uropathogenic E. coli
Veronica Åberg, Mattias Hedenström, Jerome S. Pinkner, S. J. Hultgren and Fredrik Almqvist, Org. Biomol. Chem., 2005, 3, 3886
DOI: 10.1039/b509376g
A new and efficient method for o-quinone methide intermediate generation: application to the biomimetic synthesis of the benzopyran derived natural products (±)-lucidene and (±)-alboatrin
Raphaël Rodriguez, John E. Moses, Robert M. Adlington and Jack E. Baldwin, Org. Biomol. Chem., 2005, 3, 3488
DOI: 10.1039/b508972g
Proposed mechanism for diterpene synthases in the formation of phomactatriene and taxadiene
Tetsuo Tokiwano, Taeko Endo, Tae Tsukagoshi, Hitoshi Goto, Eri Fukushi and Hideaki Oikawa, Org. Biomol. Chem., 2005, 3, 2713
DOI: 10.1039/b506411b
Synthesis and evaluation of a new non-fluorescent quencher in fluorogenic oligonucleotide probes for real-time PCR
Jonathan P. May, Lynda J. Brown, Ian van Delft, Nicola Thelwell, Kate Harley and Tom Brown, Org. Biomol. Chem., 2005, 3, 2534
DOI: 10.1039/b504759e
From -helix to 
-sheet – a reversible metal ion induced peptide secondary structure switch
Kevin Pagel, Toni Vagt, Tibor Kohajda and Beate Koksch, Org. Biomol. Chem., 2005, 3, 2500
DOI: 10.1039/b505979h
Enhanced delivery of 
-secretase inhibitor DAPT into the brain via an ascorbic acid mediated strategy
Gilles Quéléver, Philippe Kachidian, Christophe Melon, Cédrik Garino, Younes Laras, Nicolas Pietrancosta, Mahmoud Sheha and Jean Louis Kraus, Org. Biomol. Chem., 2005, 3, 2450
DOI: 10.1039/b504988a
New directions in supramolecular transition metal catalysis
Matthew J. Wilkinson, Piet W. N. M. van Leeuwen and Joost N. H. Reek, Org. Biomol. Chem., 2005, 3, 2371
DOI: 10.1039/b503407h
Synthesis and capsule formation of upper rim substituted tetra-acrylamido calix[4]arenes
Nikolai Kuhnert and Adam Le-Gresley, Org. Biomol. Chem., 2005, 3, 2175
DOI: 10.1039/b502378e
Deprotonation–electrophile trapping of terminal epoxides
David M. Hodgson, Eirene H. M. Kirton, Steven M. Miles, Stéphanie L. M. Norsikian, Nigel J. Reynolds and Steven J. Coote, Org. Biomol. Chem., 2005, 3, 1893
DOI: 10.1039/b502888d
Radical properties governing the hypoxia-selective cytotoxicity of antitumor 3-amino-1,2,4-benzotriazine 1,4-dioxides
Robert F. Anderson, Sujata S. Shinde, Michael P. Hay, Swarna A. Gamage and William A. Denny, Org. Biomol. Chem., 2005, 3, 2167
DOI: 10.1039/b502586a
Synthesis of 5/7-, 5/8- and 5/9-bicyclic lactam templates as constraints for external 
-turns
Heather M. E. Duggan, Peter B. Hitchcock and Douglas W. Young, Org. Biomol. Chem., 2005, 3, 2287
DOI: 10.1039/b503014e
Design and synthesis of aromatic inhibitors of anthranilate synthase
Richard J. Payne, Miguel D. Toscano, Esther M. M. Bulloch, Andrew D. Abell and Chris Abell, Org. Biomol. Chem., 2005, 3, 2271
DOI: 10.1039/b503802b
The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the AB-spiroacetal segment
Ian Paterson, Mark J. Coster, David Y.-K. Chen, Renata M. Oballa, Debra J. Wallace and Roger D. Norcross, Org. Biomol. Chem., 2005, 3, 2399
DOI: 10.1039/b504146e
The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the CD-spiroacetal segment
Ian Paterson, Mark J. Coster, David Y.-K. Chen, Karl R. Gibson and Debra J. Wallace, Org. Biomol. Chem., 2005, 3, 2410
DOI: 10.1039/b504148a
The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: fragment couplings, completion of the synthesis, analogue generation and biological evaluation
Ian Paterson, David Y.-K. Chen, Mark J. Coster, José L. Aceña, Jordi Bach and Debra J. Wallace, Org. Biomol. Chem., 2005, 3, 2431
DOI: 10.1039/b504151a
The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the southern hemisphere EF segment
Ian Paterson, Mark J. Coster, David Y.-K. Chen, José L. Aceña, Jordi Bach, Linda E. Keown and Thomas Trieselmann, Org. Biomol. Chem., 2005, 3, 2420
DOI: 10.1039/b504149j
Recent experimental and theoretical developments towards the observation of parity violation (PV) effects in molecules by spectroscopy
Jeanne Crassous, Christian Chardonnet, Trond Saue and Peter Schwerdtfeger, Org. Biomol. Chem., 2005, 3, 2218
DOI: 10.1039/b504212g
Click chemistry
en route to pseudo-starch
Laurence Marmuse, Sergey A. Nepogodiev and Robert A. Field, Org. Biomol. Chem., 2005, 3, 2225
DOI: 10.1039/b504293c
Selective inhibition of Trypanosoma cruzi GAPDH by bi-substrate analogues
Sylvain Ladame, Régis Fauré, Colette Denier, Faouzi Lakhdar-Ghazal and Michèle Willson, Org. Biomol. Chem., 2005, 3, 2070
DOI: 10.1039/b504703j
Divalent ligand for intramolecular complex formation to streptavidin
Joan-Antoni Farrera, Pedro Hidalgo-Fernández, Jurry M. Hannink, Jurriaan Huskens, Alan E. Rowan, Nico A. J. M. Sommerdijk and Roeland J. M. Nolte, Org. Biomol. Chem., 2005, 3, 2393
DOI: 10.1039/b505700k
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