The international home of synthetic, physical and biomolecular organic chemistry.
OBC news archive 2005

John C Vederas reports the first stereoselective synthesis of aziridine analogues of diaminopimelic acid (DAP) and their evaluation as inhibitors of DAP epimerase

The cover of the latest issue of OBC illustrates the metal-mediated crystallization-induced dynamic resolution of acid with a cheap chiral acid (D-DBTA for example).

The cover of the latest issue of OBC shows how molecules, materials and complex DNA-structures are organized at the nanometer-scale by DNA-programmed self-assembly.

The cover of the issue 21 of OBC shows a tentative binding model between substituted 2-pyridones and the periplasmic chaperone PapD found in uropathogenic Escherichia coli.
Proof that peptide secondary structures can be switched by metal ions has been provided by a model based on a well known protein motif

The cover of the latest issue of OBC shows hydrogen-bonded double rosette nanoparticles "swimming" in water, reflecting their high stability in polar solvents.

New RSS feeds for RSC journals
RSS feeds provide live updates of the latest articles direct to your PC, offering an effective way to browse journals online

Lucidene is a natural product isolated from the root bark of Uvaria lucidassp.

Hydraphiles are synthetic ion channels that function in synthetic liposomes.

An Ortho-palladated Dimethylbenzylamine Complex as a Highly Efficient Turnover Catalyst for the Decomposition of P=S Insecticides.

Gadolinium Texaphyrin-Methotrexate Conjugates. Towards Improved Cancer Chemotherapeutic Agents

Fast and flexible synthetic route to the branched tetrasaccharide structures present in many saponins, including the tomato glycoalkaloid a-tomatine.
Methyl lycotetraoside, the tetrasaccharide constituent of the tomato defence glycoalkaloid alpha-tomatine
A New Reactivity Pattern for Vinyl Bromides; Cine-Substitution via Palladium Catalysed C-N Coupling/Michael Addition Reactions

Chemical Science in China
This month the RSC showcases work from China, in recognition of the growing importance of Chinese research in the Chemical Sciences

OBC showcases work from China in issue 14, in recognition of the growing importance of Chinese research in the Chemical Sciences
Proof that peptide secondary structures can be switched by metal ions has been provided by a model based on a well known protein motif

Chemists in the US have provided verification of the structure of their acclaimed nanoscale Borromean rings, and suggest that they can now find practical applications for the rings...

A polyamide that folds back on itself, biting its tail, to make a compact three dimensional structure has been stumbled across by researchers in the UK
An improved fluorescence quencher that can analyse the products of polymerase chain reactions (PCR) has been developed by researchers in the UK
A bowl-shaped supramolecular structure has been designed and made by scientists in China and Japan

Basket-shaped molecules holding pre-organised molecules in place have helped German scientists to make huge ring compounds

One-pot multi-step synthesis: a challenge spawning innovation

On our Inside Front Cover this issue
Two-stage enzyme mediated drug release from LMWG hydrogels
OBC is delighted to announce its new editor, Dr Vikki Allen, and its first ISI impact factor, 2.194.
Take a look at what conferences the OBC Editorial team are attending this year and come and see us. We are looking forward to meeting you!

A recent Organic & Biomolecular Chemistry paper by Steven Ley and team at the University of Cambridge, UK, is among the Chemical Abstracts Service ten most requested articles.
Read the first articles from Molecular BioSystems for free, today!
The first articles for Molecular BioSystems have now been published online as Advance Articles.
New linkers for solid phase synthesis
Proposed mechanism for diterpene synthases in the formation of phomactatriene and taxadiene
Synthesis of 5/7-, 5/8- and 5/9-bicyclic lactam templates as constraints for external -turns