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An international journal for the quickest publication of high-quality research covering the breadth of synthetic, physical and biomolecular organic chemistry.
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Catalytic addition of alkyne C–H, amine N–H, and phosphine P–H bonds to carbodiimides: an efficient route to propiolamidines, guanidines, and phosphaguanidines
Wen-Xiong Zhang and Zhaomin Hou, Org. Biomol. Chem., 2008, 6, 1720
DOI: 10.1039/b800135a
Nucleoside, nucleotide and oligonucleotide based amphiphiles: a successful marriage of nucleic acids with lipids
Arnaud Gissot, Michel Camplo, Mark W. Grinstaff and Philippe Barthélémy, Org. Biomol. Chem., 2008, 6, 1324
DOI: 10.1039/b719280k
Diversity-oriented synthesis; a spectrum of approaches and results
Richard J. Spandl, Andreas Bender and David R. Spring, Org. Biomol. Chem., 2008, 6, 1149
DOI: 10.1039/b719372f
Structure-and-mechanism-based design and discovery of therapeutics for cocaine overdose and addiction
Fang Zheng and Chang-Guo Zhan, Org. Biomol. Chem., 2008, 6, 836
DOI: 10.1039/b716268e
Thiol cofactors for selenoenzymes and their synthetic mimics
Bani Kanta Sarma and Govindasamy Mugesh, Org. Biomol. Chem., 2008, 6, 965
DOI: 10.1039/b716239a
Natural and synthetic quinones and their reduction by the quinone reductase enzyme NQO1: from synthetic organic chemistry to compounds with anticancer potential
Marie A. Colucci, Gavin D. Couch and Christopher J. Moody, Org. Biomol. Chem., 2008, 6, 637
DOI: 10.1039/b715270a
Unlocking the potential of bile acids in synthesis, supramolecular/materials chemistry and nanoscience
Nonappa and Uday Maitra, Org. Biomol. Chem., 2008, 6, 657
DOI: 10.1039/b714475j
Natural products: chemical instruments to apprehend biological symphony
Mathieu Pucheault, Org. Biomol. Chem., 2008, 6, 424
DOI: 10.1039/b713022h
The [1,
3] O-to-C rearrangement: opportunities for stereoselective synthesis
Christopher G. Nasveschuk and Tomislav Rovis, Org. Biomol. Chem., 2008, 6, 240
DOI: 10.1039/b714881j
Designer aminoglycosides: the race to develop improved antibiotics and compounds for the treatment of human genetic diseases
Mariana Hainrichson, Igor Nudelman and Timor Baasov, Org. Biomol. Chem., 2008, 6, 227
DOI: 10.1039/b712690p
Chiral recognition in noncovalent bonding interactions between helicenes: right-handed helix favors right-handed helix over left-handed helix
Ryo Amemiya and Masahiko Yamaguchi, Org. Biomol. Chem., 2008, 6, 26
DOI: 10.1039/b713700a
Molecular rearrangements through thermal [1,3] carbon shifts
John E. Baldwin and Phyllis A. Leber, Org. Biomol. Chem., 2008, 6, 36
DOI: 10.1039/b711494j
2007
Current molecular design of intelligent drugs and imaging probes targeting tumor-specific microenvironments
Kazuhito Tanabe, Zhouen Zhang, Takeo Ito, Hiroshi Hatta and Sei-ichi Nishimoto, Org. Biomol. Chem., 2007, 5, 3745
DOI: 10.1039/b711244k
Design and synthesis of 
-helical peptides and mimetics
James Garner and Margaret M. Harding, Org. Biomol. Chem., 2007, 5, 3577
DOI: 10.1039/b710425a
Advances in the metallotropic [1,3]-shift of alkynyl carbenoids
Daesung Lee and Mansuk Kim, Org. Biomol. Chem., 2007, 5, 3418
DOI: 10.1039/b710379d
Asymmetric organocatalytic reductions mediated by dihydropyridines
Stephen J. Connon, Org. Biomol. Chem., 2007, 5, 3407
DOI: 10.1039/b711499k
Recent highlights in modified oligonucleotide chemistry
Alexander J. A. Cobb, Org. Biomol. Chem., 2007, 5, 3260
DOI: 10.1039/b709797m
Total synthesis approaches to natural product derivatives based on the combination of chemical synthesis and metabolic engineering
Andreas Kirschning, Florian Taft and Tobias Knobloch, Org. Biomol. Chem., 2007, 5, 3245
DOI: 10.1039/b709549j
Synthesis of azabicyclic systems using nitrogen-directed radical rearrangements
David M. Hodgson and Leonard H. Winning, Org. Biomol. Chem., 2007, 5, 3071
DOI: 10.1039/b707566a
Intramolecular cation–
interaction in organic synthesis
Shinji Yamada, Org. Biomol. Chem., 2007, 5, 2903
DOI: 10.1039/b706512b
Utilisation of plant viruses in bionanotechnology
Nicole F. Steinmetz and David J. Evans, Org. Biomol. Chem., 2007, 5, 2891
DOI: 10.1039/b708175h
Photochemical transformations of pyridinium salts: mechanistic studies and applications in synthesis
Teresa Damiano, Daniel Morton and Adam Nelson, Org. Biomol. Chem., 2007, 5, 2735
DOI: 10.1039/b706244n
Fast electron density methods in the life sciences—a routine application in the future?
Peter Luger, Org. Biomol. Chem., 2007, 5, 2529
DOI: 10.1039/b706235d
Nicotinamide adenine dinucleotide: beyond a redox coenzyme
Hening Lin, Org. Biomol. Chem., 2007, 5, 2541
DOI: 10.1039/b706887e
Functional molecules in electronic circuits
Nicolas Weibel, Sergio Grunder and Marcel Mayor, Org. Biomol. Chem., 2007, 5, 2343
DOI: 10.1039/b703287k
Oligosaccharide assembly by one-pot multi-step strategy
Yuhang Wang, Xin-Shan Ye and Li-He Zhang, Org. Biomol. Chem., 2007, 5, 2189
DOI: 10.1039/b704586g
Catalytic enantioselective construction of tetrasubstituted carbons by self-assembled poly rare earth metal complexes
Masakatsu Shibasaki and Motomu Kanai, Org. Biomol. Chem., 2007, 5, 2027
DOI: 10.1039/b704542e
Polyketides, proteins and genes in fungi: programmed nano-machines begin to reveal their secrets
Russell J. Cox, Org. Biomol. Chem., 2007, 5, 2010
DOI: 10.1039/b704420h
Designed evolution of artificial metalloenzymes: protein catalysts made to order
Marc Creus and Thomas R. Ward, Org. Biomol. Chem., 2007, 5, 1835
DOI: 10.1039/b702068f
Artificial photosynthetic systems: assemblies of slipped cofacial porphyrins and phthalocyanines showing strong electronic coupling
Akiharu Satake and Yoshiaki Kobuke, Org. Biomol. Chem., 2007, 5, 1679
DOI: 10.1039/b703405a
Polysulfides as biologically active ingredients of garlic
Ute Münchberg, Awais Anwar, Susanne Mecklenburg and Claus Jacob, Org. Biomol. Chem., 2007, 5, 1505
DOI: 10.1039/b703832a
What's new in stable radical chemistry?
Robin G. Hicks, Org. Biomol. Chem., 2007, 5, 1321
DOI: 10.1039/b617142g
Recent applications of the CuI-catalysed Huisgen azide–alkyne 1,3-dipolar cycloaddition reaction in carbohydrate chemistry
Simone Dedola, Sergey A. Nepogodiev and Robert A. Field, Org. Biomol. Chem., 2007, 5, 1006
DOI: 10.1039/b618048p
Asymmetric catalysis for the construction of quaternary carbon centres: nucleophilic addition on ketones and ketimines
Olivier Riant and Jérôme Hannedouche, Org. Biomol. Chem., 2007, 5, 873
DOI: 10.1039/b617746h
Density functional theory with dispersion corrections for supramolecular structures, aggregates, and complexes of (bio)organic molecules
Stefan Grimme, Jens Antony, Tobias Schwabe and Christian Mück-Lichtenfeld, Org. Biomol. Chem., 2007, 5, 741
DOI: 10.1039/b615319b
Robust platform for de novo production of heterologous polyketides and nonribosomal peptides in Escherichia coli
Kenji Watanabe and Hideaki Oikawa, Org. Biomol. Chem., 2007, 5, 593
DOI: 10.1039/b615589h
Recent approaches towards the asymmetric synthesis of ,-disubstituted -amino acids
Henning Vogt and Stefan Bräse, Org. Biomol. Chem., 2007, 5, 406
DOI: 10.1039/b611091f
New routes to organofluorine compounds based on ketenes and the radical transfer of xanthates
Samir Z. Zard, Org. Biomol. Chem., 2007, 5, 205
DOI: 10.1039/b615592h
Elucidating DNA damage and repair processes by independently generating reactive and metastable intermediates
Marc M. Greenberg, Org. Biomol. Chem., 2007, 5, 18
DOI: 10.1039/b612729k
The Heck–Mizoroki cross-coupling reaction: a mechanistic perspective
Jonathan P. Knowles and Andrew Whiting, Org. Biomol. Chem., 2007, 5, 31
DOI: 10.1039/b611547k
2006
From -cedrene to crinipellin B and onward: 25 years of the alkene–arene meta-photocycloaddition reaction in natural product synthesis
David Chappell and Andrew T. Russell, Org. Biomol. Chem., 2006, 4, 4409
DOI: 10.1039/b614011b
Fluorescent DNA base replacements: reporters and sensors for biological systems
James N. Wilson and Eric T. Kool, Org. Biomol. Chem., 2006, 4, 4265
DOI: 10.1039/b612284c
Synthetic studies towards the pectenotoxins: a review
Rosliana Halim and Margaret A. Brimble, Org. Biomol. Chem., 2006, 4, 4048
DOI: 10.1039/b611531b
What I have learned by using chemical model systems to study biomolecular structure and interactions
James S. Nowick, Org. Biomol. Chem., 2006, 4, 3869
DOI: 10.1039/b608953b
Amplification of chirality in liquid crystals
Rienk Eelkema and Ben L. Feringa, Org. Biomol. Chem., 2006, 4, 3729
DOI: 10.1039/b608749c
Creating carbon–carbon bonds with samarium diiodide for the synthesis of modified amino acids and peptides
Jean-Philippe Ebran, Christina M. Jensen, Sine A. Johannesen, Jakob Karaffa, Karl B. Lindsay, Rolf Taaning and Troels Skrydstrup, Org. Biomol. Chem., 2006, 4, 3553
DOI: 10.1039/b608028f
DNA nanomachines and nanostructures involving quadruplexes
Patrizia Alberti, Anne Bourdoncle, Barbara Saccà, Laurent Lacroix and Jean-Louis Mergny, Org. Biomol. Chem., 2006, 4, 3383
DOI: 10.1039/b605739j
Biaryl synthesis with control of axial chirality
Timothy W. Wallace, Org. Biomol. Chem., 2006, 4, 3197
DOI: 10.1039/b608470m
Optical resolution methods
Elemér Fogassy, Mihály Nógrádi, Dávid Kozma, Gabriella Egri, Emese Pálovics and Violetta Kiss, Org. Biomol. Chem., 2006, 4, 3011
DOI: 10.1039/b603058k
Mass spectrometric studies of non-covalent compounds: why supramolecular chemistry in the gas phase?
Bilge Baytekin, H. Tarik Baytekin and Christoph A. Schalley, Org. Biomol. Chem., 2006, 4, 2825
DOI: 10.1039/b604265a
Modeling anticancer drug–DNA interactions via mixed QM/MM molecular dynamics simulations
Katrin Spiegel and Alessandra Magistrato, Org. Biomol. Chem., 2006, 4, 2507
DOI: 10.1039/b604263p
Analysis of the reactions used for the preparation of drug candidate molecules
John S. Carey, David Laffan, Colin Thomson and Mike T. Williams, Org. Biomol. Chem., 2006, 4, 2337
DOI: 10.1039/b602413k
Catalytic asymmetric fluorinations
Carla Bobbio and Véronique Gouverneur, Org. Biomol. Chem., 2006, 4, 2065
DOI: 10.1039/b603163c
Ubiquitin: a small protein folding paradigm
Sophie E. Jackson, Org. Biomol. Chem., 2006, 4, 1845
DOI: 10.1039/b600829c
Microtiter plate based chemistry and in situ screening: a useful approach for rapid inhibitor discovery
Ashraf Brik, Chung-Yi Wu and Chi-Huey Wong, Org. Biomol. Chem., 2006, 4, 1446
DOI: 10.1039/b600055j
Electrostatic interactions in cations and their importance in biology and chemistry
Deborah M. Smith and K. A. Woerpel, Org. Biomol. Chem., 2006, 4, 1195
DOI: 10.1039/b600056h
Beyond carbohydrate binding: new directions in plant lectin research
Sneha Sudha Komath, Mannem Kavitha and Musti J. Swamy, Org. Biomol. Chem., 2006, 4, 973
DOI: 10.1039/b515446d
Synthesis of indole derivatives via isocyanides
J. Campo, M. García-Valverde, S. Marcaccini, M. J. Rojo and T. Torroba, Org. Biomol. Chem., 2006, 4, 757
DOI: 10.1039/b514946k
Supported metalloporphyrin catalysts for alkene epoxidation
Emilie Brulé and Yolanda R. de Miguel, Org. Biomol. Chem., 2006, 4, 599
DOI: 10.1039/b509985d
Bifunctional transition metal-based molecular catalysts for asymmetric syntheses
Takao Ikariya, Kunihiko Murata and Ryoji Noyori, Org. Biomol. Chem., 2006, 4, 393
DOI: 10.1039/b513564h
Arene cis-dihydrodiol formation: from biology to application
Derek R. Boyd and Timothy D. H. Bugg, Org. Biomol. Chem., 2006, 4, 181
DOI: 10.1039/b513226f
Artificial ribonucleases
Teija Niittymäki and Harri Lönnberg, Org. Biomol. Chem., 2006, 4, 15
DOI: 10.1039/b509022a
2005
Recognition and activation by ureas and thioureas: stereoselective reactions using ureas and thioureas as hydrogen-bonding donors
Yoshiji Takemoto, Org. Biomol. Chem., 2005, 3, 4299
DOI: 10.1039/b511216h
Catalytic and enantioselective allylic C–H activation with donor–acceptor-substituted carbenoids
Huw M. L. Davies and Joachim Nikolai, Org. Biomol. Chem., 2005, 3, 4176
DOI: 10.1039/b509425a
DNA-programmed assembly of nanostructures
Kurt V. Gothelf and Thomas H. LaBean, Org. Biomol. Chem., 2005, 3, 4023
DOI: 10.1039/b510551j
Oligo- and poly-nucleotides: 50 years of chemical synthesis
Colin B. Reese, Org. Biomol. Chem., 2005, 3, 3851
DOI: 10.1039/b510458k
Synthetic applications of aliphatic unsaturated -H--amino acids
Jasper Kaiser, Sape S. Kinderman, Bart C. J. van Esseveldt, Floris L. van Delft, Hans E. Schoemaker, Richard H. Blaauw and Floris P. J. T. Rutjes, Org. Biomol. Chem., 2005, 3, 3435
DOI: 10.1039/b507973j
A comparative analysis of the total syntheses of the amphidinolide T natural products
Elizabeth A. Colby and Timothy F. Jamison, Org. Biomol. Chem., 2005, 3, 2675
DOI: 10.1039/b507315b
New directions in supramolecular transition metal catalysis
Matthew J. Wilkinson, Piet W. N. M. van Leeuwen and Joost N. H. Reek, Org. Biomol. Chem., 2005, 3, 2371
DOI: 10.1039/b503407h
Chemistry and biology of wortmannin
Peter Wipf and Robert J. Halter, Org. Biomol. Chem., 2005, 3, 2053
DOI: 10.1039/b504418a
[3 + 3] Cycloadditions and related strategies in alkaloid natural product synthesis
Joseph P. A. Harrity and Olivier Provoost, Org. Biomol. Chem., 2005, 3, 1349
DOI: 10.1039/b502349c
Lectins: tools for the molecular understanding of the glycocode
Moira Ambrosi, Neil R. Cameron and Benjamin G. Davis, Org. Biomol. Chem., 2005, 3, 1593
DOI: 10.1039/b414350g
Chemical biology of protein lipidation: semi-synthesis and structure elucidation of prenylated RabGTPases
Anja Watzke, Luc Brunsveld, Thomas Durek, Kirill Alexandrov, Alexey Rak, Roger S. Goody and Herbert Waldmann, Org. Biomol. Chem., 2005, 3, 1157
DOI: 10.1039/b417573e
Bacterial death comes full circle: targeting plasmid replication in drug-resistant bacteria
Johna C. B. DeNap and Paul J. Hergenrother, Org. Biomol. Chem., 2005, 3, 959
DOI: 10.1039/b500182j
Persistent radical cations: self-association and its steric control in the condensed phase
Tohru Nishinaga and Koichi Komatsu, Org. Biomol. Chem., 2005, 3, 561
DOI: 10.1039/b418872a
Peptide–lipid interactions: insights and perspectives
John M. Sanderson, Org. Biomol. Chem., 2005, 3, 201
DOI: 10.1039/b415499a
Bioorthogonal organic chemistry in living cells: novel strategies for labeling biomolecules
Paul F. van Swieten, Michiel A. Leeuwenburgh, Benedikt M. Kessler and Herman S. Overkleeft, Org. Biomol. Chem., 2005, 3, 20
DOI: 10.1039/b412558d
2004
Ru complexes bearing bidentate carbenes: from innocent curiosity to uniquely effective catalysts for olefin metathesis
Amir H. Hoveyda, Dennis G. Gillingham, Joshua J. Van Veldhuizen, Osamu Kataoka, Steven B. Garber, Jason S. Kingsbury and Joseph P. A. Harrity, Org. Biomol. Chem., 2004, 2, 8
DOI: 10.1039/b311496c
Porphyrin–fullerene linked systems as artificial photosynthetic mimics
Hiroshi Imahori, Org. Biomol. Chem., 2004, 2, 1425
DOI: 10.1039/b403024a
Chemoselectivity in reactions of esterification
Moshe Nahmany and Artem Melman, Org. Biomol. Chem., 2004, 2, 1563
DOI: 10.1039/b403161j
Microtubule structure and its stabilisation
Linda A. Amos, Org. Biomol. Chem., 2004, 2, 2153
DOI: 10.1039/b403634d
RNAi: running interference for the cell
Oliver A. Kent and Andrew M. MacMillan, Org. Biomol. Chem., 2004, 2, 1957
DOI: 10.1039/b404932m
The merger of natural product synthesis and medicinal chemistry: on the chemistry and chemical biology of epothilones
Karl-Heinz Altmann, Org. Biomol. Chem., 2004, 2, 2137
DOI: 10.1039/b405839a
Convergent syntheses of polycyclic ethers. Illustrations of the utility of acetal-linked intermediates
Masayuki Inoue, Org. Biomol. Chem., 2004, 2, 1811
DOI: 10.1039/b407187e
Nature's many mechanisms for the degradation of oligosaccharides
Vivian L. Y. Yip and Stephen G. Withers, Org. Biomol. Chem., 2004, 2, 2707
DOI: 10.1039/B408880H
Molecular similarity: a key technique in molecular informatics
Andreas Bender and Robert C. Glen, Org. Biomol. Chem., 2004, 2, 3204
DOI: 10.1039/B409813G
A historical study of structures for communication of organic chemistry information prior to 1950
Helen Cooke, Org. Biomol. Chem., 2004, 2, 3179
DOI: 10.1039/B409980J
Representation and use of chemistry in the global electronic age
Peter Murray-Rust, Henry S. Rzepa, Simon. M. Tyrrell and Yong Zhang, Org. Biomol. Chem., 2004, 2, 3192
DOI: 10.1039/B410732B
The ins and outs of molecular encapsulation
Liam C. Palmer, Julius Rebek and Jr., Org. Biomol. Chem., 2004, 2, 3051
DOI: 10.1039/B412510J
Multivalency in supramolecular chemistry and nanofabrication
Alart Mulder, Jurriaan Huskens and David N. Reinhoudt, Org. Biomol. Chem., 2004, 2, 3409
DOI: 10.1039/b413971b
2003
HIV-1 protease: mechanism and drug discovery
Ashraf Brik and Chi-Huey Wong, Org. Biomol. Chem., 2003, 1, 5
DOI: 10.1039/b208248a
Mechanistic aspects of transition metal catalysed 1,6-diene and 1,6-enyne cycloisomerisation reactions
Guy C. Lloyd-Jones, Org. Biomol. Chem., 2003, 1, 215
DOI: 10.1039/b209175p
A chemist's view of the nitric oxide story
D. Lyn H. Williams, Org. Biomol. Chem., 2003, 1, 441
DOI: 10.1039/b209748f
New perspective of electron transfer chemistry
Shunichi Fukuzumi, Org. Biomol. Chem., 2003, 1, 609
DOI: 10.1039/b300053b
[2.2]Paracyclophane derivatives in asymmetric catalysis
Susan E. Gibson and Jamie D. Knight, Org. Biomol. Chem., 2003, 1, 1256
DOI: 10.1039/b300717k
Challenges in the design of self replicating peptides
Xiangqun Li and Jean Chmielewski, Org. Biomol. Chem., 2003, 1, 901
DOI: 10.1039/b300738c
Reagents for (ir)reversible enzymatic acylations
Ulf Hanefeld, Org. Biomol. Chem., 2003, 1, 2405
DOI: 10.1039/b302109b
Electrontransfer through DNA and metal-containing DNA
Thomas Carell, Christoph Behrens and Johannes Gierlich, Org. Biomol. Chem., 2003, 1, 2221
DOI: 10.1039/b303754a
Hydrophobic interactions and chemical reactivity
Sijbren Otto and Jan B. F. N. Engberts, Org. Biomol. Chem., 2003, 1, 2809
DOI: 10.1039/b305672d
Nucleation–elongation: a mechanism for cooperative supramolecular polymerization
Dahui Zhao and Jeffrey S. Moore, Org. Biomol. Chem., 2003, 1, 3471
DOI: 10.1039/b308788c
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