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Perspective
Org. Biomol. Chem., 2006, 4, 393 - 406, DOI: 10.1039/b513564h
Bifunctional transition metal-based molecular catalysts for asymmetric syntheses
Takao Ikariya, Kunihiko Murata and Ryoji Noyori
The discovery and development of conceptually new chiral bifunctional transition metal-based catalysts for asymmetric reactions is described. The chiral bifunctional Ru catalyst was originally developed for asymmetric transfer hydrogenation of ketones and imines and is now successfully applicable to enantioselective C–C bond formation reaction with a wide scope and high practicability. The deprotonation of 1,3-dicarbonyl compounds with the chiral amido Ru complexes leading to the amine Ru complexes bearing C- or O-bonded enolates, followed by further reactions with electrophlies gives C–C bond formation products. The present bifunctional Ru catalyst offers a great opportunity to open up new fundamentals for stereoselective molecular transformation including enantioselective C–H and C–C as well as C–O, C–N bond formation.
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