Issue 17, 2006
From the journal:

Organic & Biomolecular Chemistry

Rhodium-catalysed addition of organotrialkoxysilanes to α-substituted acrylic esters

Jonathan D. Hargrave,a   Jennifer Herbert,a   Gerwyn Bishb  and  Christopher G. Frost*a  

* Corresponding authors

a Department of Chemistry, University of Bath, Claverton Down, Bath, UK
E-mail: c.g.frost@bath.ac.uk
Fax: +44 (0)1225 386231
Tel: +44 (0)1225 386142

b Pfizer Limited, Ramsgate Road, Sandwich, Kent, UK

Abstract

The cationic rhodium complex [Rh(cod)2][BF4] effectively catalyses the 1,4-addition of organotrialkoxysilanes to α-substituted acrylic esters. The reactions are promoted by heating in an oil-bath or more conveniently in a microwave reactor allowing rapid access to a useful range of functionalised products including 2-alkyl succinates and α-amino acid derivatives.

Graphical abstract: Rhodium-catalysed addition of organotrialkoxysilanes to α-substituted acrylic esters

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/B606977K
Article type
Paper
Submitted
17 May 2006
Accepted
07 Jul 2006
First published
26 Jul 2006

Org. Biomol. Chem., 2006,4, 3235-3241

Permissions

Request permissions

Rhodium-catalysed addition of organotrialkoxysilanes to α-substituted acrylic esters

J. D. Hargrave, J. Herbert, G. Bish and C. G. Frost, Org. Biomol. Chem., 2006, 4, 3235 DOI: 10.1039/B606977K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements