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Paper
Org. Biomol. Chem., 2007, 5, 2257 - 2266, DOI: 10.1039/b704788f
Synthesis of putative chain terminators of mycobacterial arabinan biosynthesis
Iain A. Smellie, Sanjib Bhakta, Edith Sim and Antony J. Fairbanks
The synthesis of a variety of arabinose derivatives that have been modified at C-5 was achieved from D-arabinose. The 5-fluoro and 5-methoxy compounds were converted into the corresponding farnesyl phosphodiesters as putative chain terminators of mycobacterial arabinan biosynthesis. Biological testing of these materials revealed no effective anti-mycobacterial activity.
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