RSC Publishing


Publishing

 

Cover image for Organic & Biomolecular Chemistry, select for current issue

Organic & Biomolecular Chemistry

The international home of synthetic, physical and biomolecular organic chemistry.



Subscribers

  • HTML article

Free access



Perspective

Org. Biomol. Chem., 2007, 5, 2541 - 2554, DOI: 10.1039/b706887e

Nicotinamide adenine dinucleotide: beyond a redox coenzyme

Hening Lin

ADP-ribosylation using nicotinamide adenine dinucleotide (NAD+) is an important type of enzymatic reaction that affects many biological processes. A brief introductory review is given here to various ADP-ribosyltransferases, including poly(ADP-ribose) polymerase (PARPs), mono(ADP-ribosyl)transferases (ARTs), NAD+-dependent deacetylases (sirtuins), tRNA 2-phosphotransferases, and ADP-ribosyl cyclases (CD38 and CD157). Focus is given to the enzymatic reactions, mechanisms, structures, and biological functions.

Graphical abstract image for this article (ID: b706887e)