Issue 24, 2007
From the journal:

Organic & Biomolecular Chemistry

Pericosines, antitumour metabolites from the sea hare-derived fungus Periconia byssoides. Structures and biological activities†

Takeshi Yamada,a   Masashi Iritani,a   Hirohumi Ohishi,a   Kayo Tanaka,a   Katsuhiko Minoura,a   Mitsunobu Doia  and  Atsushi Numata*a  

* Corresponding authors

a Osaka University of Pharmaceutical Sciences, 4-20-1, Nasahara, Takatsuki, Osaka, Japan
E-mail: numata@gly.oups.ac.jp
Fax: +81 72 690 1005
Tel: +81 72 690 1000

Abstract

Pericosines A–E 1–5 have been isolated from a strain of Periconia byssoides originally separated from the sea hare Aplysia kurodai. Among them, pericosines C 3 and E 5 were separated as enantiomeric mixtures. Their stereostructures, except for compound 1, have been elucidated or identified on the basis of spectroscopic analyses, including 1D and 2D NMR techniques, and X-ray analysis. In addition, conformation for all the compounds has been discussed. Compounds 1–3 exhibited significant growth inhibition against tumour cell lines. Pericosine A 1 also showed significant in vivo tumour inhibitory activity. In addition, compound 1 inhibited the protein kinaseEGFR and topoisomerase II.

Graphical abstract: Pericosines, antitumour metabolites from the sea hare-derived fungus Periconia byssoides. Structures and biological activities

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Article information

DOI
https://doi.org/10.1039/B713060K
Article type
Paper
Submitted
24 Aug 2007
Accepted
08 Oct 2007
First published
26 Oct 2007

Org. Biomol. Chem., 2007,5, 3979-3986

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Pericosines, antitumour metabolites from the sea hare-derived fungus Periconia byssoides. Structures and biological activities

T. Yamada, M. Iritani, H. Ohishi, K. Tanaka, K. Minoura, M. Doi and A. Numata, Org. Biomol. Chem., 2007, 5, 3979 DOI: 10.1039/B713060K

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