Issue 6, 2008
From the journal:

Organic & Biomolecular Chemistry

Facile one-pot synthesis of 5-substituted hydantoins†

Ross G. Murray,a   David M. Whitehead,b   Franck Le Stratb  and  Stuart J. Conway*a  

* Corresponding authors

a EaStCHEM, School of Chemistry and Centre for Biomolecular Sciences, University of St Andrews, North Haugh, St Andrews, Fife, U.K.
E-mail: sjc16@st-andrews.ac.uk
Fax: +44 (0)1334 463808
Tel: +44 (0)1334 463478

b Sanofi-aventis, Department of Isotope Chemistry and Metabolite Synthesis, Alnwick Research Centre, Willowburn Avenue, Alnwick, Northumberland, U.K.

Abstract

5-Substituted and 5,5-disubstituted hydantoins are synthesised from the corresponding aldehydes or ketones, using a one-pot, gallium(III) triflate-catalysed procedure that is compatible with a range of substrates and solvents.

Graphical abstract: Facile one-pot synthesis of 5-substituted hydantoins

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Article information

DOI
https://doi.org/10.1039/B719675J
Article type
Communication
Submitted
20 Dec 2007
Accepted
04 Feb 2008
First published
14 Feb 2008

Org. Biomol. Chem., 2008,6, 988-991

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Facile one-pot synthesis of 5-substituted hydantoins

R. G. Murray, D. M. Whitehead, F. Le Strat and S. J. Conway, Org. Biomol. Chem., 2008, 6, 988 DOI: 10.1039/B719675J

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