Communication

Org. Biomol. Chem., 2008, 6, 1895 - 1897, DOI: 10.1039/b804701d

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Epigenetic remodeling of the fungal secondary metabolome

Russell B. Williams, Jon C. Henrikson, Ashley R. Hoover, Andrlynn E. Lee and Robert H. Cichewicz

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Fungi treated with DNA methyltransferase and histone deacetylase inhibitors exhibited natural product profiles with enhanced chemical diversity demonstrating that small-molecule epigenetic modifiers are effective tools for rationally controlling the native expression of fungal biosynthetic pathways and generating new biomolecules.

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