RSC Publishing


Publishing

 

Cover image for Organic & Biomolecular Chemistry, select for current issue

Organic & Biomolecular Chemistry

The international home of synthetic, physical and biomolecular organic chemistry.



Subscribers

Non-subscribers

Free access



Paper

Org. Biomol. Chem., 2009, 7, 2976 - 2980, DOI: 10.1039/b901670h

Complementary chemoenzymatic routes to both enantiomers of febrifugine

Marloes A. Wijdeven, Rutger J. F. van den Berg, Roel Wijtmans, Peter N. M. Botman, Richard H. Blaauw, Hans E. Schoemaker, Floris L. van Delft and Floris P. J. T. Rutjes

Two complementary strategies for the synthesis of febrifugine are detailed based on previously developed chemoenzymatic approaches to the 3-hydroxypiperidine skeleton. The introduction of the quinazolone-containing side chain in both strategies was based on an N-acyliminium ion-mediated coupling reaction.

Graphical abstract image for this article (ID: b901670h)