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Paper

Org. Biomol. Chem., 2009, 7, 4037 - 4044, DOI: 10.1039/b910015f

Homophymines B–E and A1–E1, a family of bioactive cyclodepsipeptides from the sponge Homophymia sp.

Angela Zampella, Valentina Sepe, Filomena Bellotta, Paolo Luciano, Maria Valeria D'Auria, Thierry Cresteil, Cécile Debitus, Sylvain Petek, Christiane Poupat and Alain Ahond

Nine new cyclodepsipeptides, homophymines B–E ( 2–5) and A1–E1 ( 1a–5a), were isolated from the polar extracts of the sponge Homophymia sp. The new structures, featuring new polyketide-derived end groups, were determined by interpretation of NMR and MS data. The configurations of the new end groups was secured by the application of J-based configurational analysis. Homophymines displayed very potent antiproliferative activity (IC50 in the nM range) against a panel of human cancer cell lines.

Graphical abstract image for this article (ID: b910015f)