Issue 6, 2010

An efficient synthesis of (±)-frondosin B using a Stille–Heck reaction sequence

Abstract

A concise, convergent synthesis of (±)-frondosin B has been developed based on the application of a Stille–Heck reaction sequence of 2-chloro-5-methoxybenzo[b]furan-3-yl triflate and 2-(3-butenyl)-3-(trimethylstannyl)cyclohex-2-enone giving the racemic natural product in a 34% overall yield.

Graphical abstract: An efficient synthesis of (±)-frondosin B using a Stille–Heck reaction sequence

Supplementary files

Article information

Article type
Communication
Submitted
23 Nov 2009
Accepted
19 Jan 2010
First published
01 Feb 2010

Org. Biomol. Chem., 2010,8, 1290-1292

An efficient synthesis of (±)-frondosin B using a Stille–Heck reaction sequence

K. Masters and B. L. Flynn, Org. Biomol. Chem., 2010, 8, 1290 DOI: 10.1039/B924542A

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