Issue 11, 2010

Acid–base properties of functionalised tripodal polyamines and their interaction with nucleotides and nucleic acids

Abstract

Novel, highly positively charged tripodal polyamines with appended heterocyclic moieties revealed an intriguing panel of protonation species within the biologically relevant range. Studied compounds bind nucleotide monophosphates by mostly electrostatic interactions but only the imidazole analogue showed selectivity toward UMP in respect to other nucleotides. Strong binding of all the studied compounds to both ds-DNA and ds-RNA is to some extent selective toward the latter, showing rather rare RNA over DNA preference.

Graphical abstract: Acid–base properties of functionalised tripodal polyamines and their interaction with nucleotides and nucleic acids

Supplementary files

Article information

Article type
Paper
Submitted
12 Jan 2010
Accepted
12 Mar 2010
First published
26 Mar 2010

Org. Biomol. Chem., 2010,8, 2567-2574

Acid–base properties of functionalised tripodal polyamines and their interaction with nucleotides and nucleic acids

A. Sornosa-Ten, M. T. Albelda, J. C. Frías, E. García-España, J. M. Llinares, A. Budimir and I. Piantanida, Org. Biomol. Chem., 2010, 8, 2567 DOI: 10.1039/C000124D

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