_tcm18-11415.gif )
An international journal for the quickest publication of high-quality research covering the breadth of synthetic, physical and biomolecular organic chemistry.
OBC cover gallery 2005
Previous OBC covers are available for browsing here
Cover Gallery
The cover illustrates two diastereomers of aziridino-diaminopimelate (azi-DAP), an irreversible inactivator of DAP epimerase (H. influenzae), approaching the monomeric disulfide form of the target enzyme.
DOI: 10.1039/b513409a
The metal-mediated crystallization-induced dynamic resolution of acid with a cheap chiral acid (D-DBTA for example). This method is a promising one for the resolution of acids.
DOI: 10.1039/b510170k
Molecules, materials and complex DNA-structures are organized at the nanometer-scale by DNA-programmed self-assembly.
DOI: 10.1039/b510551J
A tentative binding model between substituted 2-pyridones and the periplasmic chaperone PapD found in uropathogenic Escherichia coli.
DOI: 10.1039/B509376G
Hydrogen-bonded double rosette nanoparticles "swimming" in water, reflecting their high stability in polar solvents.
DOI: 10.1039/B508449K
Lucidene is a natural product isolated from the root bark of Uvaria lucidassp.
DOI: 10.1039/b508972g
Hydraphiles are synthetic ion channels that function in synthetic liposomes. This report shows that they are cytotoxic to Gram-negative and Gram-positive bacteria, yeast, and mammalian cells. Their cellular toxicity compares favorably with that of other synthetic ionophores and rivals the potency of natural antibiotics. Whole cell patch clamping with mammalian cells confirms a channel mechanism in living cells suggesting that this family may comprise novel and flexible pharmacological agents.
DOI: 10.1039/b512658b
An Ortho-palladated Dimethylbenzylamine Complex as a Highly Efficient Turnover Catalyst for the Decomposition of P=S Insecticides. Mechanistic Studies of the Methanolysis of Some P=S Containing Phosphorothioate Triesters, Brown et al.
DOI: 10.1039/B508917d
The illustration provides a schematic representation of the anti-proliferative effect produced by an ester-linked conjugate between methotrexate, an antifolate cancer chemotherapeutic, and motexafin gadolinium, an experimental cancer agent demonstrating selective tumour localization. The ester linkage undergoes cleavage within the A549 human lung cancer cells used for analysis and, presumably as a consequence, this conjugate displays greater activity at short incubation times than does methotrexate alone. Neither the amide conjugate, which is stable under these in vitro conditions, nor motexafin gadolinium on its own, shows any appreciable activity under these conditions.
DOI: 10.1039/b511742a
Fast and flexible synthetic route to the branched tetrasaccharide structures present in many saponins, including the tomato glycoalkaloid alpha-tomatine. S. Nepogodiev et al.
DOI: 10.1039/B508752J
The cover image highlights the promise of more efficient synthetic chemistry, where new methods allow the environmentally sustainable production of non-natural materials. This ideal situation offers a solution to the current course of synthetic chemistry that continues to deplete natural resources at a rapid pace. D.Tyler McQuade et al.
DOI: 10.1039/B506621M
Rock, Paper, Scissors is a decision making game played by substituting these 3 elements with hand signals. Rock beats Scissors and loses to Paper. Paper beats Rock and loses to Scissors. Scissors beats Paper and loses to Rock. (All elements stalemate against themselves.). Analogously, in the system described here Rock beats Scissors (gel cannot be cut by the enzyme), but Scissors beats Paper (enzyme can cut low molecular weight gelator (LMWG) molecules in solution).
DOI: 10.1039/b510381a
The combination of different methods for studying the rate of shuttling motions in [2]Rotaxanes, controlled by electrostatic interactions, Christoph Schalley et al.
DOI: 10.1039/b506756a
Strongly enhanced fluorescence is generated due to the formation of self-assembly in tartaricacid-assisted binary organogel, Ran Lu et al.
DOI: 10.1039/B504945H
The challenging 3D-structure of altohyrtin A, a potent anticancer agent of marine sponge origin, synthesised using boron aldol methodology to enable its further preclinical development. Ian Paterson et al.
DOI: 10.1039/B504146E
The figure shows how two monodentate ligands can be assembled to form a bidentate chelating ligand to be used in transition metal catalysis. This is just one of the new strategies in the area of supramolecular catalysis assembly.
DOI: 10.1039/b508078a
Recent experimental and theoretical developments towards the observation of parity violation (PV) effects in molecules by spectroscopy, Jeanne Crassous et al
DOI: 10.1039/B504212G
The magnesium ion in the active site of Serratia marcescens anthranilate synthase coordinates the C-1 carboxylate of chorismate. Hydrogen bonding interactions further bind the substrate into the active site.
DOI: 10.1039/b507491f
The chart shows that the axial chirality is induced in biphenyldiol (highlighted in gold) by complex formation with chiral diamine. The proton transfer equilibrium in the hydrogen-bonding diamine-diol complex drives the formation of a ternary complex, resulting in effective chiral induction.
DOI: 10.1039/b506701b
Rocuronium bromide (steroid, orange) enters the cavity of a cyclodextrin; changes in the conformation of both the cyclodextrin and steroid ensure efficient binding. This presents a new horizon in the field of anaesthesia.
DOI: 10.1039/B505953B
[3 + 3] Cycloadditions and related strategies in alkaloid natural product synthesis, Harrity and Provoost
DOI: 10.1039/b502349c
A thiourea based receptor first forms a genuine H-bond complex with acetate, then, on further anion addition, undergoes deprotonation; the less acidic urea containing receptor stops at the complex formation.
DOI: 10.1039/b504450m
Advanced approaches for the characterization of a de novo designed antiparallel coiled coil peptide.
DOI: 10.1039/b418167k
Technomimetic molecules are molecules designed to imitate and transpose the motions of objects at the molecular level. On this cover are presented three macroscopic objects, a gear, a motor and a wheelbarrow with their molecular analogues in the centre of the viewfinder.
DOI: 10.1039/b503576g
Synthesis and characterisation of highly emissive and kinetically stable lanthanide complexes suitable for usage in cellulo, Parker et al.
DOI: 10.1039/b418964g
Thermotropic liquid-crystalline peptide derivatives: oligo(glutamic acid)s forming hydrogen-bonded columns, Kato et al.
DOI: 10.1039/b416474a
Evidence for dimer formation by an amphiphilic heptapeptide that mediates chloride and carboxyfluorescein release from liposomes, Pajewski et al
DOI: 10.1039/b417009a
Peptide-lipid interactions: insights and perspectives, Sanderson
DOI: 10.1039/b415499a
Organocatalysis with proline derivatives: improved catalysts for the asymmetric Mannich, nitro-Michael and aldol reactions, Cobb et al.
DOI: 10.1039/B414742A
RSS feed