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Organic & Biomolecular Chemistry

The international home of synthetic, physical and biomolecular organic chemistry.



Read more about OBC Hot Articles

A borono-nucleotide

Hot Article: borono-analogues of nucleotides

16 September 2009

Synthesis of borono-analogues of nucleotides



Helical nanostructures

Hot Article: An unusual twist for functional assemblies

13 August 2009

An international team of researchers have stumbled across some unique coil-shaped nanostructures when investigating photoresponsive functional assemblies



fragment of a molecule

Hot Article: Taking the strain off spiropentane synthesis

17 July 2009

US chemists have developed an easy, direct route to a class of small, strained organic molecules that could be used in drug discovery.



Representation of a molecule binding to a protein

Hot Article: Investigating parasitic invasion

04 June 2009

Chemists have identified that peroxiredoxin II is inhibited by a molecule that stops parasitic invasion.



Picture showing part of a reaction scheme

Hot Article: Chemoenzymatic synthesis of aszonalenin natural products

A highly selective one-step synthesis of natural products using enzymes to convert polycyclic precursors into aszonalenins



DABCO base

Hot Article: Base-catalysed coupling gets the green light

04 March 2009

Chemists have developed a solvent- and metal-free coupling reaction for creating carbon-carbon bonds



micro positron emission tomography image of mouse treated with radiotracer

Hot Article: A better view of cell death

23 February 2009

A new class of radio-labelled compounds that can image dying cells could be used to show if drugs are effective at blocking or inducing cell death



Peptoid

Hot Article: Deciphering peptoid relationships

13 February 2009

Helen Blackwell and Sarah Fowler from the University of Wisconsin-Madison, US, focus on the relationship between peptoid structure and function



Chiral ruthenium complex

Hot Article: Breaking the mould with a clay catalyst

27 January 2009

Japanese chemists have combined a clay with a metal complex to make an effective catalyst for a selective organic reaction



prodrug structure

Hot Article: X-ray marks the spot for prodrug

22 December 2008

Japanese scientists have made a radiation-triggered prodrug that could improve chemotherapy



Burgess hot paper

Hot Article: Non-covalent delivery

02 December 2008

Scientists in the US develop non-covalent carriers with the potential to mediate the transport of proteins into cells



nanoparticle-peptide interaction

Hot Article: Coiled coil calls the shots

18 November 2008

German scientists use peptides and pH to control the organisation of nanoparticles



Crime scene tape, DNA and a fingerprint

Forensic science hots up

31 October 2008

Could fluorescent probes offer DNA profiling at the scene of a crime?



Ring-contracted product

Rings feel the squeeze

22 September 2008

French scientists have discovered an unprecedented ring contraction reaction that can be used as a key route to promising heterocyclic scaffolds



Wood hot paper

Seeking protection from radicals

03 September 2008

UK scientists investigate deuterium as a protecting group for C-H bonds during radical reactions.



Lyosensor blue emits blue fluorescence in the presence of acid

Hot Paper: Bright future for functional molecules

07 May 2008

Molecules can display display logic, sense, numeracy and utility and communicate with humans using light signals.



A piece of DNA

Hot Paper: Fungi wake up to new natural products

29 April 2008

A ground-breaking method of getting fungi to produce normally 'hidden' compounds has been demonstrated by US scientists.



Modelled binding of a blebbistatin analogue

Hot Paper: Tuning chemical tools

24 April 2008

A combination of chemistry and biology is helping find new tools for protein research.



Ultrasonic approach to forming carbon bonds

Hot Paper: Ultrasonic approach to forming carbon bonds

10 April 2008

Electrocatalysis helps overcome unwanted oxidation of nucleophiles



chiral compound formed by the intramolecular reaction of triynes

Hot Paper: Recent additions to chiral synthesis

31 March 2008

Strategies for enantioselective transition metal-catalysed cycloadditions are discussed.



The role of chemical synthesis in structure elucidation

Hot Paper: Chemical synthesis solves structures

25 March 2008

The stereostructures of three natural products are determined through chemical syntheses.



nudibranch red eggmass

Hot Paper: Sea slug macrocycle synthesised

06 March 2008

The total synthesis of a complex natural product isolated from nudibranch eggmasses is reported.



mitotic behaviour

Hot Paper: Diversity-oriented synthesis

27 February 2008

The varied molecular architectures present in Nature are mimicked by preparing skeletally diverse small molecules.



tetra-urea calix[4]arenes

Hot Paper: New insight into guest exchange

20 February 2008

The rate of guest exchange in calixarene capsules depends on the size of the groups attached to the narrow rim.



malonates used for the synthesis of 5-O-feruloylquinic acids

Hot Paper: A new brew for coffee derivatives

13 February 2008

Scientists in Switzerland have optimised a novel synthesis of a polyphenolic compound found in coffee beans.



New fluorescent sensors for reactive oxygen species

Hot Paper: Making sense of ROS

17 December 2007

Two new fluorescent sensors for reactive oxygen species are reported.



PASSflow system

Hot Paper: PASSport to enzyme immobilisation

13 November 2007

A microreactor concept for immobilised enzymes is disclosed.