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Organic & Biomolecular Chemistry

An international journal for the quickest publication of high-quality research covering the breadth of synthetic, physical and biomolecular organic chemistry.



Read more about OBC Hot Articles

Lyosensor blue emits blue fluorescence in the presence of acid

Hot Paper: Bright future for functional molecules

07 May 2008

Molecules can display display logic, sense, numeracy and utility and communicate with humans using light signals.



A piece of DNA

Hot Paper: Fungi wake up to new natural products

29 April 2008

A ground-breaking method of getting fungi to produce normally 'hidden' compounds has been demonstrated by US scientists.



Modelled binding of a blebbistatin analogue

Hot Paper: Tuning chemical tools

24 April 2008

A combination of chemistry and biology is helping find new tools for protein research.



Ultrasonic approach to forming carbon bonds

Hot Paper: Ultrasonic approach to forming carbon bonds

10 April 2008

Electrocatalysis helps overcome unwanted oxidation of nucleophiles



chiral compound formed by the intramolecular reaction of triynes

Hot Paper: Recent additions to chiral synthesis

31 March 2008

Strategies for enantioselective transition metal-catalysed cycloadditions are discussed.



The role of chemical synthesis in structure elucidation

Hot Paper: Chemical synthesis solves structures

25 March 2008

The stereostructures of three natural products are determined through chemical syntheses.



nudibranch red eggmass

Hot Paper: Sea slug macrocycle synthesised

06 March 2008

The total synthesis of a complex natural product isolated from nudibranch eggmasses is reported.



mitotic behaviour

Hot Paper: Diversity-oriented synthesis

27 February 2008

The varied molecular architectures present in Nature are mimicked by preparing skeletally diverse small molecules.



tetra-urea calix[4]arenes

Hot Paper: New insight into guest exchange

20 February 2008

The rate of guest exchange in calixarene capsules depends on the size of the groups attached to the narrow rim.



malonates used for the synthesis of 5-O-feruloylquinic acids

Hot Paper: A new brew for coffee derivatives

13 February 2008

Scientists in Switzerland have optimised a novel synthesis of a polyphenolic compound found in coffee beans.



New fluorescent sensors for reactive oxygen species

Hot Paper: Making sense of ROS

17 December 2007

Two new fluorescent sensors for reactive oxygen species are reported.



PASSflow system

Hot Paper: PASSport to enzyme immobilisation

13 November 2007

A microreactor concept for immobilised enzymes is disclosed.



molecular modelling of the cavitand and adamantyl maleimide complex

Hot Paper: Cavitand catalysis

05 November 2007

A deep cavitand catalyses the Diels-Alder reaction of bound maleimides.



deuterium-labeled bicyclo[4.2.0]oct-2-ene

Hot Paper: Atoms on the move

18 October 2007

US researchers investigate the mechanism of [1,3] carbon shifts.



bismuth triflate-catalysed three-component Mannich-type reaction

Hot Paper: Bismuth catalysts for Mannich-type reactions

12 October 2007

Canadian researchers have developed an efficient bismuth-catalysed Mannich-type 3-component reaction.



Gold nanoparticles initiate free radical oxidations and halogen abstractions

Hot Paper: Radicals in a spin

02 October 2007

UK researchers investigate gold nanoparticle-initiated free radical oxidations and halogen abstractions.



microcin J25

Hot Paper: Peptides get knotted

01 August 2007

UK researchers report for the first time the in vitro maturation of a unique peptide knot.



Graphical Abstract

Hot Paper: Cure for Chagas' disease a step closer

30 July 2007

Combining chemical and enzymatic approaches brings promise of a cure for a debilitating parasitic disease.



A proteasome

Hot Paper: Mixed-up inhibitors

25 April 2007

Dutch researchers have taken a mix-and-match approach to probing the proteasome.



Graphical Abstract

Hot Paper: A new fluorescent probe for reactive oxygen species

04 April 2007

A new sensor that can efficiently monitor damaging reactive oxygen species (ROS) in biological samples has been developed.



Graphical Abstract

Hot Article: Natural products inspire organometallic drugs

22 March 2007

Exploring the use of metal complexes in synthesising new molecular scaffolds and discovering new compounds.



Graphical Abstract

Hot Paper: Shedding light on porphyrin problem

21 March 2007

Until now it was assumed that the rapid decay of fused porphyrin oligomers is due to the small energy gap, however new research shows that this is not the case.



Image from Lighting the way to larger peptides Hot paper

Hot Paper: Lighting the way to larger peptides

06 February 2007

US Chemists have developed a photochemical approach to stitching together peptides and proteins.



Graphical Abstract

Hot Paper: Playing tag with molecular libraries

15 January 2007

Marked small molecule libraries: a truncated approach to molecular probe design