A novel ring transformation of 5-carbamoyluracils into barbituric acids
Abstract
Heating of 5-thiocarbamoyl-(3) and 5-carbamoyl-3-methyl-1-phenyluracil derivatives (5) in ethanolic sodium ethoxide causes a novel ring transformation to give 5-anilinomethylene-4-thiobarbituric acid (2) and 5-anilinomethylenebarbituric acids (6), respectively.