Issue 1, 1990
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Novel ring transformations of 5-cyanouracils into 2-thiocytosines, 2,4-diaminopyrimidines, and pyrimido[4,5-d]pyrimidines by the reaction with thioureas and guanidines

Kosaku Hirota,   Hironao Sajiki,   Yukio Kitade  and  Yoshifumi Maki  

Abstract

The reaction of 5-cyanouracils with thioureas and guanidines causes novel pyrimidine-to-pyrimidine ring transformations. Thus, 1,3-disubstituted 5-cyanouracils (1) react with thiourea and guanidines to give the corresponding 5-carbamoyl-2-thiocytosines (2) and 2,4-diamino-5-carbamoylpyrimidines (5), respectively. On the other hand, 5-cyanouracils (8) possessing a phenyl group at the 1-position react with thioureas to give 7-aminopyrimido[4,5-d]pyrimidine-2,4-diones (9).

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Article information

DOI
https://doi.org/10.1039/P19900000123
Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1990, 123-128

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Novel ring transformations of 5-cyanouracils into 2-thiocytosines, 2,4-diaminopyrimidines, and pyrimido[4,5-d]pyrimidines by the reaction with thioureas and guanidines

K. Hirota, H. Sajiki, Y. Kitade and Y. Maki, J. Chem. Soc., Perkin Trans. 1, 1990, 123 DOI: 10.1039/P19900000123

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