A new journal for findings of exceptional significance from across the chemical sciences
Contents list for Chemical Science, issue 1, 2010
Cover
Front cover
Chem. Sci., 2010, 1, 1
DOI: 10.1039/c0sc90002h
Front/Back Matter
Inside front cover
Chem. Sci., 2010, 1, 2
DOI: 10.1039/c0sc90004d
Contents
Chem. Sci., 2010, 1, 3
DOI: 10.1039/c0sc90001j
Editorial
Introducing Chemical Science– Recognition starts here
Chem. Sci., 2010, 1, 11
DOI: 10.1039/c005351c
It is with great pleasure that we welcome you to the first issue of Chemical Science, the Royal Society of Chemistry's new flagship general chemistry journal.
Perspective
Diamine ligands in copper-catalyzed reactions
David S. Surry and Stephen L. Buchwald,
Chem. Sci., 2010, 1, 13
DOI: 10.1039/c0sc00107d
Enhanced HTML article available
The use of diamine ligands has allowed Cu-catalyzed cross-coupling reactions to be performed under mild conditions and endowed these reactions with significantly increased substrate scope. In this review the development of these methods and their applications in pharmaceutical research, natural products synthesis and materials science are described.
Minireview
Modifying MOFs: new chemistry, new materials
Seth M. Cohen,
Chem. Sci., 2010, 1, 32
DOI: 10.1039/c0sc00127a
Postsynthetic modification of metal–organic frameworks provides access to new functionality in these hybrid materials.
Edge Articles
The organocatalytic three-step total synthesis of (+)-frondosin B
Maud Reiter, Staffan Torssell, Sandra Lee and David W. C. MacMillan,
Chem. Sci., 2010, 1, 37
DOI: 10.1039/c0sc00204f Enhanced HTML article available
A concise enantioselective total synthesis of (+)-frondosin B is described which requires a total of three chemical steps. X-Ray crystallographic data, deuterium labeling, and chemical correlation studies provide evidence as to the correct absolute stereochemical assignment of (+)-frondosin B.
Encapsulation of the uranyl dication
Stephan Beer, Orion B. Berryman, Dariush Ajami and Julius Rebek Jr.,
Chem. Sci., 2010, 1, 43
DOI: 10.1039/c0sc00116c
We report the application of self-assembly to the sequestration of uranyl ion. The assembly presents the ion with convergent carboxylate ligands, isolates it from solvent, encapsulates it with aromatic panels and allows its extraction from aqueous solutions in the presence of excess brine.
Discovery of an orexin receptor positive potentiator
Jiyong Lee, M. Muralidhar Reddy and Thomas Kodadek,
Chem. Sci., 2010, 1, 48
DOI: 10.1039/c0sc00197j Enhanced HTML article available
A microarray-based screening effort followed by hit optimization has provided the first positive potentiator of the orexin receptors.
Vibrational overtone excitation in electron mediated energy transfer at metal surfaces
Russell Cooper, Igor Rahinov, Zhisheng Li, Daniel Matsiev, Daniel J. Auerbach and Alec M. Wodtke,
Chem. Sci., 2010, 1, 55
DOI: 10.1039/c0sc00141d
We report observations of vibrational overtone (
> 1) excitation in molecular collisions with a metal surface.
Following the self assembly of supramolecular MOFs using X-ray crystallography and cryospray mass spectrometry
Georg Seeber, Geoffrey J. T. Cooper, Graham N. Newton, Mali H. Rosnes, De-Liang Long, Benson M. Kariuki, Paul Kögerler and Leroy Cronin,
Chem. Sci., 2010, 1, 62
DOI: 10.1039/c0sc00264j
The self assembly of two gigantic supramolecular copper(II)-cis,trans-1,3,5-triaminocyclohexane based MOFs, directed by anion control, is probed by cryospray mass spectrometry.
Peptide-coated, self-assembled M12L24 coordination spheres and their immobilization onto an inorganic surface
Masatoshi Ikemi, Takashi Kikuchi, Sachiko Matsumura, Kiyotaka Shiba, Sota Sato and Makoto Fujita,
Chem. Sci., 2010, 1, 68
DOI: 10.1039/c0sc00198h
A nano-sized M12L24 coordination sphere coated with 24 hexapeptide aptamers was efficiently self-assembled from 12 Pd(II) ions and 24 bent ligands. The high density of aptamers covering the sphere resulted in irreversible immobilization on a Ti surface.
Chiral pyridyl phosphinites with large aryl substituents as efficient ligands for the asymmetric iridium-catalyzed hydrogenation of difficult substrates
David H. Woodmansee, Marc-André Müller, Marcus Neuburger and Andreas Pfaltz,
Chem. Sci., 2010, 1, 72
DOI: 10.1039/c0sc00223b Enhanced HTML article available
A flexible synthesis was developed for chiral pyridyl phosphinite ligands, which were successfully applied in the asymmetric hydrogenation of 
-substituted ,
-unsaturated esters and dihydronaphthalenes.
Macrocyclization of enzyme-based supramolecular polymers
Maartje M. C. Bastings, Tom F. A. de Greef, Joost L. J. van Dongen, Maarten Merkx and E. W. Meijer,
Chem. Sci., 2010, 1, 79
DOI: 10.1039/c0sc00108b
The ring–chain supramolecular polymerization mechanism characterizes the self-assembly mechanism of flexible biological building blocks.
The conformer resolved ultraviolet photodissociation of morpholine
Thomas A. A. Oliver, Graeme A. King and Michael N. R. Ashfold,
Chem. Sci., 2010, 1, 89
DOI: 10.1039/c0sc00119h
Distinct resolved sets of photoproducts are observed from photodissociation of the two neutral conformers of morpholine via H(Rydberg) atom photofragment translational spectroscopy.
Controlled rotary motion of light-driven molecular motors assembled on a gold film
Gregory T. Carroll, Michael M. Pollard, Richard van Delden and Ben L. Feringa,
Chem. Sci., 2010, 1, 97
DOI: 10.1039/c0sc00162g
A light-driven unidirectional molecular motor is assembled on a semi-transparent gold film and shown to undergo rotary motion.
Symmetry and polar-
effects on the dynamics of enshrouded aryl-alkyne molecular rotors
Arif R. Karim, Anthony Linden, Kim K. Baldridge and Jay S. Siegel,
Chem. Sci., 2010, 1, 102
DOI: 10.1039/c0sc00117a
The torsional energy profile of tolan-based molecular rotors, comprising two 2,6-diarylphenylethyne stators attached para across a benzene rotator, depends on the rotor symmetry and the rotator-to-stator polar- interactions.
Definition of the uptake mechanism and sub-cellular localisation profile of emissive lanthanide complexes as cellular optical probes
Elizabeth J. New, Aileen Congreve and David Parker,
Chem. Sci., 2010, 1, 111
DOI: 10.1039/c0sc00105h Enhanced HTML article available
Emissive Eu and Tb complexes enter cells by macropinocytosis giving intracellular levels of up to 0.4 mM without perturbing cellular homeostasis.
Enabling tetracationic cyclophane production by trading templates
Chi-Hau Sue, Subhadeep Basu, Albert C. Fahrenbach, Alexander K. Shveyd, Sanjeev K. Dey, Youssry Y. Botros and J. Fraser Stoddart,
Chem. Sci., 2010, 1, 119
DOI: 10.1039/c0sc00176g
Chessboards and chimneys come to mind when looking at the two different polymorphs of the now readily accessible 
blue box,
thanks to the use of some cuckoo chemistry.
Enlarging the reactive cone of acceptance by exciting the C–H bond in the O(3P) + CHD3 reaction
Fengyan Wang and Kopin Liu,
Chem. Sci., 2010, 1, 126
DOI: 10.1039/c0sc00186d
Exciting the CH stretching mode of CHD3 promotes its reactivity towards the O(3P) atom by enlarging the cone of acceptance.
Cell surface-based differentiation of cell types and cancer states using a gold nanoparticle-GFP based sensing array
Avinash Bajaj, Subinoy Rana, Oscar R. Miranda, Joseph C. Yawe, D. Joseph Jerry, Uwe H. F. Bunz and Vincent M. Rotello,
Chem. Sci., 2010, 1, 134
DOI: 10.1039/c0sc00165a
Differentiation of cell types and cancer states has been achieved using a nanoparticle-GFP supramolecular complexes based sensor array.
Front/Back Matter
Back cover
Chem. Sci., 2010, 1, 139
DOI: 10.1039/c0sc90003f
