DNA-analogous structures from deoxynucleophosphates and polylysine by ionic self-assembly

Byram H. Ozer; Bernd Smarsly; Markus Antonietti; Charl F. J. Faul

doi:10.1039/B515626B

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

DNA-analogous structures from deoxynucleophosphates and polylysine by ionic self-assembly†

Byram H. Ozer,^a Bernd Smarsly,^a Markus Antonietti^a and Charl F. J. Faul*^ab

Author affiliations

* Corresponding authors

^a Max Planck Institute of Colloids and Interfaces, Research Campus Golm, Potsdam, Germany

^b Inorganic and Materials Chemistry, School of Chemistry, University of Bristol, Bristol, UK
E-mail: charl.faul@bristol.ac.uk
Fax: + 44 117 929 0509

Abstract

Here we show that ionic self-assembly of simple biological tectons can be used to synthesize stable and highly ordered molecular structures. In particular, nucleotides and charged polypeptides can be assembled to form a complex analogous to DNA under relatively benign conditions. The combination of polylysine and pure dGMP leads to a fourfold ladder structure stabilizing an interior G-quartet structure by four polypeptide scaffolds. Making use of the Watson–Crick G∶C base pairing motive leads to double-stranded complexes. Interestingly, these complexes show stable DNA-like organization in aqueous solutions, as proven by gel electrophoresis and intercalation experiments

Download options Please wait...

Supplementary files

elemental analyses of PL complexes; sign of the structure factors vs scattering vector; electron density map for the 2D hexagonal structure obtained for the sample; SAXS curves; IR spectra, and ethidium bromide and coommasie-stained gels. PDF (696K)

Article information

DOI: https://doi.org/10.1039/B515626B
Article type: Paper
Submitted: 03 Nov 2005
Accepted: 24 Jan 2006
First published: 08 Feb 2006

Download Citation

Soft Matter, 2006,2, 329-336

Permissions

Request permissions

DNA-analogous structures from deoxynucleophosphates and polylysine by ionic self-assembly

B. H. Ozer, B. Smarsly, M. Antonietti and C. F. J. Faul, Soft Matter, 2006, 2, 329 DOI: 10.1039/B515626B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Soft Matter

DNA-analogous structures from deoxynucleophosphates and polylysine by ionic self-assembly†

Abstract

Supplementary files

Article information

Download Citation

Permissions

DNA-analogous structures from deoxynucleophosphates and polylysine by ionic self-assembly

Social activity

Search articles by author

Spotlight

Advertisements